A review of 12 patients with proven Aspergillus osteomyelitis was undertaken between July 2004 and October 2007. Aspergillus fumigatus was most commonly identified (n = 9). Voriconazole was commonly administered (11/12; 91.7%), and 9 (75.0%) underwent surgery. Seven (58.3%) responded to treatment, and 12-week mortality was 25.0% (3/12). Survival was improved with surgical intervention (P = 0.05).

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diagmicrobio.2008.12.005DOI Listing

Publication Analysis

Top Keywords

aspergillus osteomyelitis
8
osteomyelitis review
4
review cases
4
cases identified
4
identified prospective
4
prospective antifungal
4
antifungal therapy
4
therapy alliance
4
alliance registry
4
registry review
4

Similar Publications

Article Synopsis
  • A case of spondylodiscitis caused by Aspergillus fumigatus was successfully treated with isavuconazole after the patient showed severe intolerance to the standard treatment, voriconazole.
  • Isavuconazole is a newer antifungal that has been shown to be just as effective as voriconazole for invasive aspergillosis, with fewer side effects and no need for serum level monitoring.
  • While current research on isavuconazole specifically for spondylodiscitis is limited, this case adds to the evidence supporting its use in treating this serious condition.
View Article and Find Full Text PDF
Article Synopsis
  • Malignant otitis externa (MOE) is a serious condition often linked to fungi, especially in people with weakened immune systems, prompting a review of fungal cases (FMOE) among patients.
  • The study analyzed 10 articles covering 197 patients, mostly older adults (average age 65.9 years), highlighting that a significant number (78.7%) had conditions like diabetes or cancer.
  • Most patients received conservative treatment focusing on antifungals like itraconazole, with a notable 4% mortality rate attributed to factors such as late diagnosis and cranial nerve issues, suggesting that early antifungal treatment could enhance patient outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • The study evaluates the use of apparent diffusion coefficient (ADC) values in MRI to differentiate between fungal and bacterial skull base osteomyelitis (SBO).
  • Researchers conducted a retrospective review of 142 SBO patients and found that the most common pathogens were Pseudomonas, Aspergillus, and Staphylococcus aureus.
  • Despite noting a difference in the average ADC values between infected and normal tissues, the results showed no significant difference between the ADC values of bacterial and fungal SBO, highlighting the importance of early biopsies for accurate diagnosis.
View Article and Find Full Text PDF

Chronic granulomatous disease (CGD) is a disorder of immunity characterized by phagocyte dysfunction. Mold infections in patients with CGD are often severe and disseminated. We present patient characteristics, microbiological data, and outcomes for 26 patients with CGD who received hematopoietic cell transplantation (HCT) or gene therapy-modified cells (GT) between 2008 and 2019, with proven fungal infection either before or during their transplant.

View Article and Find Full Text PDF

Xanthogranulomatous osteomyelitis of pubic bone mimicking neoplasm: a case report and literature review.

BMC Musculoskelet Disord

October 2024

Department of Orthopedic Surgery, College of Medicine, Chung-Ang University Hospital, Chung-Ang University, Seoul, Republic of Korea.

Article Synopsis
  • - Xanthogranulomatous osteomyelitis (XO) is a rare bone disease that appears as an osteolytic lesion, and it's crucial to distinguish it from other similar conditions like bone tumors.
  • - A 23-year-old woman presented with pelvic pain and febrile episodes, leading to the discovery of an osteolytic lesion in the pubic bone, which was later confirmed to be caused by an Aspergillus fungal infection after surgical removal.
  • - This case highlights the importance of considering fungal infections in XO cases and suggests that specific antifungal treatments should be included in the management plan, as XO can occur due to such infections despite being predominantly associated with bacteria.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!