AI Article Synopsis
- The study aimed to measure the distance between tongue base salivary tissue and the hyoid bone, as well as to analyze protein differences in tissue remnants after Sistrunk surgery.
- Researchers measured the distance using tissue from 10 adult cadavers and conducted immunohistochemistry on samples from pediatric patients, finding an average distance of 3.3 mm and specific proteins in different tissue types.
- The results indicated that MUC5AC is unique to thyroglossal duct remnants, while MUC7 is found in salivary tissue; amylase was present in both but not helpful for tissue distinction.
Article Abstract
Objective: To establish the distance between tongue base salivary tissue and hyoid. Also, to identify protein differences between thyroglossal duct (TGD) remnants and salivary tissue in order to distinguish drainage source post Sistrunk surgery.
Methods/setting: The anterior neck block was obtained from 10 adult cadavers with no known neck pathology. The distance between the normal salivary tissue and hyoid was measured histologically. Immunohistochemistry (IHC) was then performed on 20 archived tissue blocks from pediatric patients post Sistrunk surgery to identify the presence of amylase, MUC5AC (tracheobronchial mucin), and MUC7 (salivary mucin) within the excised specimen.
Results: Average distance between salivary tissue and the hyoid within adult human cadavers was 3.3 mm (range, 1.0-4.2 mm). IHC revealed all excised TGD remnants contained amylase and MUC5AC but none contained MUC7. Both amylase and MUC7 were present within adjacent salivary tissues.
Conclusions: Salivary tissue of the tongue base normally resides an average of 3.3 mm from the hyoid within the adult population. Biochemical analysis showed MUC5AC was specific for TGD remnants while MUC7 was specific for salivary tissue. Amylase does not distinguish between the two tissues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.otohns.2008.12.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Salivary Flow Rate in Patients with Sjögren's Syndrome: Correlations with Salivary Gland Ultrasound Findings and Biomarkers of Disease Activity.
Int J Mol Sci
December 2024
Cardiology Department, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Sjögren's syndrome (SS) is a slowly progressive, chronic autoimmune inflammatory condition characterized by the affliction of the exocrine glands, with issues that derive from it markedly decreasing the quality of life of these patients. Salivary gland involvement can be identified through imaging methods. Among them, salivary gland ultrasonography (SGUS) is used as a diagnostic and prognostic tool in pSS.
View Article and Find Full Text PDFPRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.
J Exp Clin Cancer Res
January 2025
Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Background: Adenoid cystic carcinoma (ACC) is a rare glandular malignancy, commonly originating in salivary glands of the head and neck. Given its protracted growth, ACC is usually diagnosed in advanced stage. Treatment of ACC is limited to surgery and/or adjuvant radiotherapy, which often fails to prevent disease recurrence, and no FDA-approved targeted therapies are currently available.
View Article and Find Full Text PDFSystematic identification of pathological mechanisms, prognostic biomarkers and therapeutic targets by integrating lncRNA expression variation in salivary gland mucoepidermoid carcinoma.
Sci Rep
January 2025
Department of Oral and Maxillofacial Surgery, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, China.
Biological processes intricately intertwine with tumorigenesis, significantly influencing treatment outcomes and prognosis. However, the mechanisms fostering mucoepidermoid carcinoma (MEC) remain inadequately elucidated. This research utilizes expression profiles of lncRNAs from clinical MEC tissues and matched normal glandular tissues, integrating public data to explore the biological mechanisms and immune microenvironment characteristics of tumorigenesis.
View Article and Find Full Text PDFAnatomical variations in Eurasian wolf (Canis lupus lupus) (Carnivora: Canidae) of the salivary glands: A histological and histochemical investigation.
PLoS One
January 2025
Department of Morphological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
The study involved a gross anatomical description of the parotid gland, mandibular gland, monostomatic sublingual gland, polystomatic sublingual gland, and zygomatic gland in 12 adult Eurasian wolves (Canis lupus lupus) (wild free-ranging individuals and their zoo counterparts), including their morphometry and microscopic evaluation using hematoxylin & eosin, mucicarmine, azan trichrome, PAS, AB pH 1.0, AB pH 2.5; AB pH 2.
View Article and Find Full Text PDFLarge recurrent sialoliths in a residual Wharton duct after sialoadenectomy: Two case reports and literature review.
Medicine (Baltimore)
January 2025
Department of Oral and Maxillofacial Surgery.
Rationale: When gland-preserving treatments are unsuccessful, sialoadenectomy is typically conducted for patients afflicted with submandibular gland diseases. The definitive treatment modality for these individuals is the removal of both the gland and the associated ducts. During surgery, the gland and the majority of the ducts can be excised utilizing the lateral transcervical approach, with residual ducts unlikely to develop pathology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!