Background: We evaluated the effect of age on the results of a cornflakes breath test that determines the efficiency of starch digestion.
Material/methods: Two groups of 12 fasted healthy subjects (group Y, 24.7+/-0.6 years; and group MA, 49.7+/-1.3 years) consumed a 521-kcal test breakfast of 100 g cornflakes naturally abundant in 13C (-14.00 per thousand 13C enrichment relative to the Vienna Pee Dee belemnite standard). Then, the 13CO2 concentration was measured in samples of exhaled air collected over 9 hours.
Results: We noted a maximum momentary 13CO2 breath excretion of 7.54+/-0.19% dose/h at 298 +/- 15 minutes in group Y and 7.70+/-0.27% dose/h at 305+/-10 minutes in group MA. The group curves of the cumulative 13C recovery in breath air exhibited a virtually overlapping time course. The 6-hour cumulative 13C recovery was 29.33+/-0.70%dose in group Y and 29.87+/-1.18%dose in group MA. Extending the collection period from 6 to 9 hours produced an increase in the cumulative 13C recovery of 58.4+/-2.1%. The 9-hour cumulative 13C recovery was 46.58+/-1.04%dose in the Y group and 46.93+/-1.84%dose and the MA group.
Conclusions: An age difference of more than 2 decades was not associated with a negative impact on the in vivo ability to digest starch. The reference values of the cornflakes breath test can be derived from healthy subjects in a relatively wide age range.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The effect of feeding order of forage and oats on metabolic and digestive responses related to gastric emptying in horses.
J Anim Sci
December 2024
Department of Paraclinical Sciences, Norwegian University of Life Sciences, Ås, Norway.
Feeding order of forage and concentrate might affect gastric emptying and subsequently digestion in horses. The objective of this study was to measure gastric emptying in combination with metabolic and digestive responses in the plasma and caecum, respectively, when changing the feeding order of oats (O) and hay (H) (oats first then hay: O-H vs. hay first then oats: H-O).
View Article and Find Full Text PDFPreparation and kinetic studies of a new antibacterial sodium alginate gelatin hydrogel composite.
Sci Rep
November 2024
Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, 21321, Egypt.
This study involved synthesis of a novel antibacterial heterocyclic compound, sodium 2-(2-(3-phenyl-1, 2, 4-oxadiazol-5-yl) phenoxy) acetate abbreviated as Na-POPA. Further development of a biocompatible, pH-responsive hydrogel drug carrier prepared utilizing the natural polymers gelatin and sodium alginate. The compound loaded on the hydrogel represented new drug delivery system.
View Article and Find Full Text PDFChemical shift prediction in C NMR spectroscopy using ensembles of message passing neural networks (MPNNs).
J Magn Reson
November 2024
University of East Anglia, Norwich Research Park, NR7 6TJ, United Kingdom. Electronic address:
This study reports a deep learning approach that utilises message passing neural networks (MPNNs) for predicting chemical shifts in C NMR spectra of small molecules. MPNNs were trained on two distinct datasets: one with approximately 4000 labelled structures and another with over 40,000. To reduce stochastic variation, an ensemble framework was implemented, which is simple to deploy on multiple nodes of a High-Performance Computing facility.
View Article and Find Full Text PDFPerformance of empirical and model-based classifiers for detecting sucrase-isomaltase inhibition using theC-sucrose breath test.
J Breath Res
September 2024
Department of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, United States of America.
TheC-sucrose breath test (C-SBT) has been proposed to estimate sucrase-isomaltase (SIM) activity and is a promising test for SIM deficiency, which can cause gastrointestinal symptoms, and for intestinal mucosal damage caused by gut dysfunction or chemotherapy. We previously showed how various summary measures of theC-SBT breath curve reflect SIM inhibition. However, it is uncertain how the performance of these classifiers is affected by test duration.
View Article and Find Full Text PDFPrimate hibernation: The past, present, and promise of captive dwarf lemurs.
Ann N Y Acad Sci
October 2024
Department of Biology, Duke University, Durham, North Carolina, USA.
The dwarf lemurs (Cheirogaleus spp.) of Madagascar are the only obligate hibernators among primates. Despite century-old field accounts of seasonal lethargy, and more recent evidence of hibernation in the western fat-tailed dwarf lemur (Cheirogaleus medius), inducing hibernation in captivity remained elusive for decades.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!