Wnt-signaling has recently been identified as a regulator of a number of endocrine functions in health and disease in addition to its original attribution to developmental biology. Wnts are extracellular ligands on frizzled receptors and on lipoprotein receptor-related protein co-receptors. Ligand binding leads eventually to the activation of intracellular signaling cascades; based on the involvement of the transcriptional co-activator beta-catenin it can be distinguished between canonical (i.e. beta-catenin) and non-canonical Wnt-signaling. Recent studies revealed that canonical Wnt-signaling regulates the function of endocrine organs and contributes to a number of endocrine disorders. In this review, we would like to focus on a) recent mechanistic data on Wnts in pancreatic beta-cell function; b) human genetic studies on Wnt signaling in type 2 diabetes mellitus; c) crosstalk between adipocytes and endocrine cells through Wnt-signaling molecules (with a focus on the role of Wnt-signaling in adrenocortical cells).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1530/EJE-08-0831 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy and safety of Danggui Liuhuang Decoction combined with antithyroid drugs for hyperthyroidism: A systematic review and meta-analysis.
J Ethnopharmacol
December 2024
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. Electronic address:
Ethnopharmacological Relevance: Hyperthyroidism is a prevalent clinical endocrine disorder. Danggui Liuhuang Decoction (DGLHD), a traditional Chinese herbal medicine formula, has shown potential benefits for patients with hyperthyroidism in recent studies. However, the clinical efficacy and safety of DGLHD have not been systematically evaluated.
View Article and Find Full Text PDFSynergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway.
Ecotoxicol Environ Saf
December 2024
The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, China. Electronic address:
Nanoplastics (NPs) are an emerging class of pollutants. They can act as a"Trojan horse" to change the bioavailability and toxicity of heavy metals in the environment. However, research on the combined toxicity of heavy metals and NPs is scarce, especially during the critical developmental period of adolescence.
View Article and Find Full Text PDFInternational web-based survey of patients with non-hydrocephalic symptomatic pineal cysts.
Acta Neurochir (Wien)
December 2024
Department of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Objectives: To report the results of an international patient-reported survey that adds to the growing body of evidence surrounding the role of surgery in the management of a subset of patients with non-hydrocephalic symptomatic pineal cyst.
Design: An international web-based survey of health outcomes in patients with nhSPC.
Subjects: All survey participants who self-reported a diagnosis of symptomatic pineal cyst without hydrocephalus after radiological imaging.
Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder.
BMC Psychiatry
December 2024
Department of Psychiatry, First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Background: The clinical characteristics of major depressive disorder (MDD) in adolescents show notable gender-related differences, but the cause of these differences is still not understood. The current research concentrates on the changes in neurometabolism and neuroendocrine function, aiming to identify differences in endocrine function and brain metabolism between male and female adolescents with MDD.
Methods: A total of 121 teenagers diagnosed with MDD (43 males and 78 females) were enlisted as participants.
Characterising immune-related adverse events in different types of cancer among Chinese patients receiving immune checkpoint inhibitors.
Sci Rep
December 2024
Faculty of Health Science and Sports, Macao Polytechnic University, Macao, China.
Immune checkpoint inhibitors (ICIs) have been approved for monotherapy and combined therapy with chemotherapy and/or radiotherapy in China since 2018. The number of patients receiving ICIs has significantly increased in recent years, and the collection and analysis of this data are crucial for a comprehensive understanding of their clinical outcomes and adverse effects. The effects of ICIs may vary among different ethnic groups, and there is a lack of such data in the Chinese population.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!