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Albumin determined by bromocresol green leads to erroneous results in routine evaluation of patients with chronic kidney disease.
Clin Chem Lab Med
November 2023
Division of Laboratory Medicine, Radboudumc, Nijmegen, The Netherlands.
Objectives: Measurement of plasma albumin is pivotal for clinical decision-making in patients with chronic kidney disease (CKD). Routinely used methods as bromocresol green (BCG) and bromocresol purple (BCP) can suffer from aselectivity, but the impact of aselectivity on the accuracy of plasma albumin results of CKD-patients is still unknown. Therefore, we evaluated the performance of BCG-, BCP- and JCTLM-endorsed immunological methods in patients with various stages of CKD.
View Article and Find Full Text PDFWearable Dual-Signal NH Sensor with High Sensitivity for Non-invasive Diagnosis of Chronic Kidney Disease.
Langmuir
March 2023
Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
NH gas in human exhaled breath contains abundant physiological information related to human health, especially chronic kidney disease (CKD). Unfortunately, up to now, most wearable NH sensors show inevitable defects (low sensitivity, easy to be interfered by the environment, etc.), which may lead to misdiagnosis of CKD.
View Article and Find Full Text PDFImpact of Albumin Assays in the Diagnosis of Malnutrition in Hemodialysis Patients: A Cohort Study.
J Ren Nutr
March 2023
CHU Bordeaux, Department of Biochemistry, Pellegrin Hospital, Bordeaux, France; University of Bordeaux, INSERM, Biology of Cardiovascular Diseases U1034, Pessac, France. Electronic address:
Article Synopsis
- The study evaluates different methods for measuring plasma albumin in hemodialysis patients to accurately diagnose malnutrition.
- It highlights significant variations in albumin levels based on the testing method, with existing thresholds for hypoalbuminemia leading to misclassifications.
- The authors suggest adjusting hypoalbuminemia cut-off values for two methods (bromocresol purple and immunoturbidimetry) to improve diagnostic accuracy in identifying malnutrition among these patients.
[Comparison of three albumin assay methods: a need for standardization within a healthcare area].
Ann Biol Clin (Paris)
December 2021
Laboratoire de biologie médicale, Groupe hospitalier Bretagne-Sud, Lorient.
Albumin is a main biomarker of denutrition severity. Since 2019, the French National Authority of Health (HAS) recommends an immunologic technique as a reference for measuring albuminemia. In a context of partial recovery by the laboratory of GHBS (using colorimetric method with bromcresol purple) of the biological activity of the dialysis center, until then carried out by the Ouest biology - Biolor laboratory (using colorimetric method with bromcresol green) and in order to standardize practices in the healthcare sector, we compared 3 albumin assay techniques: immunoturbidimetric (Diagam), BCG (Siemens), BCP (Siemens) on Siemens Atellica PLCs.
View Article and Find Full Text PDFRemoval of Bromocresol Green from aqueous solution by electro-Fenton and electro-Fenton-like processes with different catalysts: laboratory and kinetic model investigation.
Water Sci Technol
November 2021
Faculty of Chemistry, Warsaw University of Technology, Noakowski street 3, 00-664, Warsaw, Poland E-mail:
This study presents the removal of triarylmethane dye Bromocresol Green from aqueous solution by the electro-Fenton process. As catalysts five different cations were used: Fe, Ce, Ni, Mn, and Co. They play crucial roles in the whole process because they react with HO producing hydroxyl radicals that are capable of breaking down dye molecules.
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