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The Causal Role of Ectopic Fat Deposition in the Pathogenesis of Metabolic Syndrome.
Int J Mol Sci
December 2024
Department of Internal Medicine, Erasmus Medical Center (Erasmus MC), Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Consuming a "modern" Western diet and overnutrition may increase insulin secretion. Additionally, nutrition-mediated hyperinsulinemia is a major driver of ectopic fat deposition. The global prevalence of metabolic syndrome is high and growing.
View Article and Find Full Text PDFSurgery for an Uncommon Pathology: Pancreatic Metastases from Renal Cell Carcinoma-Indications, Type of Pancreatectomy, and Outcomes in a Single-Center Experience.
Medicina (Kaunas)
December 2024
Department of General Surgery, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Fundeni Street No. 258, 022328 Bucharest, Romania.
: The role of surgery in pancreatic metastases of renal cell carcinoma (PM_RCC) is highly controversial, particularly in the context of modern systemic therapies and the conflicting results of studies published so far. This study aims to explore a single surgical center experience (including mainly pancreatic resections) regarding the indications, the type of pancreatectomies, and early and long-term outcomes for PM_RCC. : The data of all patients with surgery for PM_RCC (from 1 January 2002 to 31 December 2023) were retrospectively assessed, and potential predictors of survival were explored.
View Article and Find Full Text PDFLAMP Reaction in Plant Disease Surveillance: Applications, Challenges, and Future Perspectives.
Life (Basel)
November 2024
Department of Agricultural, Food, Environmental and Forestry Science and Technology (DAGRI), Plant Pathology and Entomology Section, University of Florence, Piazzale delle Cascine 28, 50144 Florence, Italy.
Movements of plant pathogenic microorganisms in uncontaminated areas occur today at an alarming rate, driven mainly by global trade and climate change. These invaders can trigger new disease outbreaks able to impact the biodiversity and economies of vast territories and affect a variety of ecosystem services. National and supranational regulatory deficiencies, such as inadequate quarantine measures and ineffective early pathogen detection at ports of entry, exacerbate the issue.
View Article and Find Full Text PDFRestricted Daily Exposure of Environmental Enrichment: Bridging the Practical Gap from Animal Studies to Human Application.
Int J Environ Res Public Health
November 2024
Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Daily restricted environmental enrichment (REE) refers to limited, structured periods of enrichment aimed at improving both physical and cognitive well-being in animals and humans. This review explores the significance of REE, focusing on studies that investigate 2 and 3 h daily enrichment protocols. Through an analysis of 21 key studies, this paper highlights how even brief periods of REE can lead to substantial improvements in brain plasticity, cognitive function, and stress resilience.
View Article and Find Full Text PDFAn 'Index of Oro-dental Disease': A holistic method for understanding the impacts of different risk factors on oral health in archaeological populations.
Int J Paleopathol
January 2025
School of Archaeology and Ancient History, University of Leicester, United Kingdom. Electronic address:
Objective: To gain a more holistic understanding of oral health in the past by producing an 'Index of Oro-dental Disease' (IOD), incorporating multiple oro-dental diseases and accounting for differences in antemortem/postmortem alveolar bone and tooth loss.
Materials: UK Adult Dental Health Survey, 2009 anonymised dataset (N = 6206). Archaeological dental data from skeletal individuals from medieval and post-medieval Barton-upon-Humber, North Lincolnshire (N = 214, 1150-1855) and St James's Gardens Burial Ground, London (N = 281, 1789-1853).
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