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The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.
Animal Model Exp Med
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GemPharmatech Chengdu Co., Ltd., Chengdu, China.
Background: The emerging incidence of pathogenic liver conditions is turning into a major concern for global health. Induction of pyroptosis in hepatocytes instigates cellular disintegration, which in turn liberates substantial quantities of pro-inflammatory intracellular substances, thereby accelerating the advancement of liver fibrosis. Consequently, directing therapeutic efforts towards inhibiting pyroptosis could potentially serve as an innovative approach in managing inflammation related chronic hepatic disorders.
View Article and Find Full Text PDFEffects of Aging on Glucose and Lipid Metabolism in Mice.
Aging Cell
December 2024
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Aging is accompanied by multiple molecular changes that contribute to aging associated pathologies, such as accumulation of cellular damage and mitochondrial dysfunction. Tissue metabolism can also change with age, in part, because mitochondria are central to cellular metabolism. Moreover, the cofactor NAD, which is reported to decline across multiple tissues during aging, plays a central role in metabolic pathways such as glycolysis, the tricarboxylic acid cycle, and the oxidative synthesis of nucleotides, amino acids, and lipids.
View Article and Find Full Text PDFCorrection: Relationship between breastfeeding and hepatic steatosis in women with previous gestational diabetes mellitus.
Int Breastfeed J
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Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, 681 Samsen Road, Dusit District, Bangkok, 10300, Thailand.
Black soldier fly larvae: a one health approach to investigate gut, and organ health and meat quality response in slow-growing chickens.
BMC Vet Res
December 2024
Department of Veterinary Sciences, University of Turin, Grugliasco, Italy.
Background: The inclusion of sustainable protein sources in poultry feed has become essential for improving animal welfare in livestock production. Black soldier fly larvae are a promising solution due to their high protein content and sustainable production. However, most research has focused on fast-growing poultry breeds, while the effects on native breeds, such as the Bianca di Saluzzo, are less explored.
View Article and Find Full Text PDFKnockdown of RASD1 improves MASLD progression by inhibiting the PI3K/AKT/mTOR pathway.
Lipids Health Dis
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Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, 519000, People's Republic of China.
Background: There is still no reliable therapeutic targets and effective pharmacotherapy for metabolic dysfunction-associated steatotic liver disease (MASLD). RASD1 is short for Ras-related dexamethasone-induced 1, a pivotal factor in various metabolism processes of Human. However, the role of RASD1 remains poorly illustrated in MASLD.
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