Background: The management of thoracoomphalopagus twins depends on gestational age and life expectancy of the fetuses. Vaginal route of delivery is limited to small nonviable fetuses. Cesarean section should be reserved for larger fetuses or when the life expectancy of the fetuses is of concern.
Cases: The first case was that of heavily malformed fetuses of 28 weeks in preterm labor, delivered vaginally according to their parent's request, but the fusion between fetuses was torn cephalad. The second case was diagnosed and underwent cesarean section at her 29th gestational week, but her babies were lost after birth due to cardiorespiratory arrest. The third case was 34 weeks pregnant and not diagnosed until birth. Presentation of the first fetus was vertex, while the other was breech. Totally 3,700 g twins were delivered by vaginal route without any serious complication.
Conclusion: Successful vaginal delivery of the third trimester fetuses is possible. The technique of the delivery is important.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s00404-009-1007-2 | DOI Listing |
Int J Pharm
January 2025
Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China. Electronic address:
Amyotrophic lateral sclerosis (ALS) presents a substantial challenge due to its complex nature, limited effective treatment options, and modest benefits from current therapies in slowing disease progression. This study explores the potential of intranasal delivery to enhance the CNS delivery of riluzole (RLZ), a standard ALS treatment which is subject to blood-brain barrier efflux mechanisms. Additionally, the impact of elacridar (ELC), an efflux pump inhibitor, on IN RLZ CNS bioavailability was examined.
View Article and Find Full Text PDFPLoS One
January 2025
Swansea Community Farm, Swansea, Wales, United Kingdom.
Background: As an umbrella term, social prescribing offers varied routes into society which promise to support, enhance, and empower individual citizens to take control of their own health and wellbeing. Globally healthcare systems are struggling to cope with the increasing demands of an ageing population and the NHS (UK) is no exception. Social prescribing is heralded as a means to relieve the burden on primary care and provide support for the 20% of patients whose needs are non-medical.
View Article and Find Full Text PDFClin Cancer Res
January 2025
University of Leeds, Leeds, United Kingdom.
Background: Effective treatment for patients with metastatic cancer is limited, particularly for colorectal cancer patients with metastatic liver lesions (mCRC), where accessibility to numerous tumours is essential for favourable clinical outcomes. Oncolytic viruses (OVs) selectively replicate in cancer cells; however, direct targeting of inaccessible lesions is limited when using conventional intravenous or intratumoural administration routes.
Methods: We conducted a multi-centre, dose-escalation, phase I study of vaccinia virus, TG6002, via intrahepatic artery (IHA) delivery in combination with the oral pro-drug 5-fluorocytosine to fifteen mCRC patients.
Biointerphases
January 2025
Department of Pharmaceutical Sciences, State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning 116081, China.
The special structure of eyes and the existence of various physiological barriers make ocular drug delivery one of the most difficult problems in the pharmaceutical field. Considering the problems of patient compliance, local administration remains the preferred method of drug administration in the anterior part of eyes. However, local administration suffers from poor bioavailability, need for frequent administration, and systemic toxicity.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Faculty of Chemistry, University of Gdansk, Wita Stwosza, 6380308, Gdańsk, Poland.
The medical and cosmetic industries have developed in recent years, there has been a growing demand for new materials. Gold nanoparticles (Au NPs) and chitosan (CS) have been known and used for many years. Unfortunately, despite their numerous advantages and possible applications, such materials may possess certain disadvantages and limitations that constitute a problem in medical or cosmetic applications.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!