AI Article Synopsis
- The synthesis involves using a nickel catalyst to create 2-substituted oxazoles by coupling 2-methylthio-oxazole with different organozinc compounds.
- This method also allows for a one-pot, selective synthesis of unsymmetrical 2,5-disubstituted oxazoles, making it more efficient.
- Overall, this approach offers significant benefits over earlier techniques and works well alongside existing cyclodehydration methods.
Article Abstract
The synthesis of 2-substituted oxazoles is achieved via nickel-catalyzed cross-coupling reaction of 2-methylthio-oxazole and various organozinc reagents. An extension of this method is demonstrated with a chemoselective, one-pot synthesis of unsymmetrical 2,5-disubstituted oxazoles. This synthesis of 2- and 2,5-substituted oxazoles using this method provides great advantages over previous methods for these compounds and is highly complementary to current cyclodehydration strategies.
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| http://dx.doi.org/10.1021/ol900260g | DOI Listing |
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