Objective: Impurity profiling of seized methamphetamine may play an important role in the determination of the synthetic method employed and the criminal investigations of drug traffic routes.

Methods: A sample of methamphetamine was dissolved in buffer solution. Impurities were extracted with ethyl acetate containing four internal standards (n-decane, n-pentadecane, n-eicosane and n-octacosane) and analyzed by GC-MS.

Results: These data are suggestive of ephedrine/pseudoephedrine as the main precursor of the methamphetamine samples seized during 2006-2007. Six samples of selected eight samples were synthesized via the more specific ephedrine/hydriodic acid/red phosphorus method.

Conclusion: Ephedrine/pseudoephedrine is common material used to synthesize methamphetamine.

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