[Polymorphism of vitamin D receptor and lead poisoning genetic polymorphism in Han, Uygur and Kazak child in China].

Objective: To explore the relationship between the polymorphism of vitamin D receptor (VDR) and genetic polymorphism in Han, uygur and Kazak child in China.

Methods: The VDR genotyping was determined by PCR-RFLP in 469 Han, 443 Uygur and 516 Kazak child from Xinjiang province. The correlation between the polymorphism of VDR and blood lead levels were explored.

Results: The frequencies of the allele BsmIB and BsmIb in Han child were 6% and 94%, and in Uygur were 18% and 82%, in Kazak were 43% and 57% respectively. Statistic correlation between the distribution of VDR-BsmI alleles and the blood lead level was found in Han and Uygur.

Conclusion: The genetic susceptibility of VDR polymorphism to lead toxicity may exhibit in a lead dose-dependent manner.