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Hybrid Carbohydrate-Lipid Nanocarriers: In Vitro Efficacy Gene-Rated by Association of UV-Absorbers and Raspberry Polyphenols Rich-Fraction.
Pharmaceuticals (Basel)
December 2024
Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology POLITEHNICA of Bucharest, Polizu No 1, 011061 Bucharest, Romania.
The study aims to investigate an improved version of lipid nanocarriers (NLCs) (formulated with functional coconut butter and marula oil) by designing hyaluronic acid (HA) decorated NLC co-loaded with dual UVA (butyl methoxy dibenzoyl methane, BMDBM), UVB absorbers (ethyl-hexyl-salicylate, EHS) and a Raspberry rich polyphenols fraction (RPRF) for development of more natural NLC-based to-pical formulations. : Quality and quantitative attributes of classic- and HA-NLC have been assigned based on particle size, electrokinetic potential, encapsulation efficiency, spectroscopic characteristics, and high-resolution mass spectrometry. To establish the performance profile of antioxidant activity, release of active substances, sun blocking action, and photostability, in vitro studies were conducted.
View Article and Find Full Text PDFThe Real-World Clinical Outcomes of Heavily Pretreated HER2+ and HER2-Low Metastatic Breast Cancer Patients Treated with Trastuzumab Deruxtecan at a Single Centre.
Curr Oncol
December 2024
Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Background: Trastuzumab deruxtecan (TDXd) is an antibody-drug conjugate that has demonstrated impressive activity in randomized controlled clinical trials in the context of patients with HER2-amplified and HER2-low metastatic breast cancer. We aimed to review the activity and adverse event profile of TDXd in heavily pretreated breast cancer patients in real practice.
Methods: We describe a single-center retrospective case series of metastatic breast cancer patients who were treated with TDXd.
Physics-Based Machine Learning to Predict Hydration Free Energies for Small Molecules with a Minimal Number of Descriptors: Interpretable and Accurate.
J Phys Chem B
January 2025
School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Hydration free energy (HFE) of molecules is a fundamental property having importance throughout chemistry and biology. Calculation of the HFE can be challenging and expensive with classical molecular dynamics simulation-based approaches. Machine learning (ML) models are increasingly being used to predict HFE.
View Article and Find Full Text PDFStrong Interfacial Interaction in Polarized Ferroelectric Heterostructured Nanosheets for Highly Efficient and Selective Photocatalytic CO Reduction.
Small
January 2025
State Key Laboratory of Electromechanical Integrated Manufacturing of High-Performance Electronic Equipments, School of Mechano-Electronic Engineering, Xidian University, Xi'an, 710071, China.
Heterojunctions are sustainable solutions for the photocatalytic CO reduction reaction (CORR) by regulating charge separation behavior at the interface. However, their efficiency and product selectivity are severely hindered by the inflexible and weak built-in electric field and the electronic structure of the two phases. Herein, ferroelectric-based heterojunctions between polarized bismuth ferrite (BFO(P)) and CdS are constructed to enhance the interfacial interactions and catalytic activity.
View Article and Find Full Text PDFLondon taxi drivers exploit neighbourhood boundaries for hierarchical route planning.
Cognition
March 2025
Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London, UK. Electronic address:
Humans show an impressive ability to plan over complex situations and environments. A classic approach to explaining such planning has been tree-search algorithms which search through alternative state sequences for the most efficient path through states. However, this approach fails when the number of states is large due to the time to compute all possible sequences.
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