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WD-repeat containing protein-61 regulates endometrial epithelial cell adhesion indicating an important role in receptivity.
Mol Hum Reprod
November 2024
Department of Obstetrics, Gynecology and Newborn Health, University of Melbourne, Parkville, Melbourne, Australia.
Endometrial receptivity is crucial for successful embryo implantation during early pregnancy. The human endometrium undergoes remodeling within each menstrual cycle to prepare or become receptive to an implanting blastocyst in the mid-secretory phase. However, the mechanisms behind these changes are not fully understood.
View Article and Find Full Text PDFmiR-23b-3p regulates human endometrial epithelial cell adhesion implying a role in implantation.
Reproduction
April 2023
Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
Article Synopsis
- miR-23b-3p levels increase in the human endometrium during the receptive phase, which is crucial for successful implantation of the blastocyst.* -
- The study used techniques like qPCR and hybridization to explore miR-23b-3p expression and its effects on endometrial cells' adhesion to trophoblasts, highlighting its role in fertility.* -
- Results showed that while miR-23b-3p enhances adhesion in fertile endometrial cells, it does not have the same effect in infertile cells, indicating potential mechanisms behind endometrial receptivity.*
Infertile human endometrial organoid apical protein secretions are dysregulated and impair trophoblast progenitor cell adhesion.
Front Endocrinol (Lausanne)
January 2023
Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC, Australia.
Introduction: Embryo implantation failure leads to infertility. As an important approach to regulate implantation, endometrial epithelial cells produce and secrete factors apically into the uterine cavity in the receptive phase to prepare the initial blastocyst adhesion and implantation. Organoids were recently developed from human endometrial epithelium with similar apical-basal polarity compared to endometrial gland making it an ideal model to study endometrial epithelial secretions.
View Article and Find Full Text PDFNanofiber/hydrogel core-shell scaffolds with three-dimensional multilayer patterned structure for accelerating diabetic wound healing.
J Nanobiotechnology
January 2022
College of Chemical and Materials Sciences, Shanghai Normal University, No. 100 Guilin Road, Shanghai, 200234, People's Republic of China.
Impaired angiogenesis is one of the predominant reasons for non-healing diabetic wounds. Herein, a nanofiber/hydrogel core-shell scaffold with three-dimensional (3D) multilayer patterned structure (3D-PT-P/GM) was introduced for promoting diabetic wound healing with improved angiogenesis. The results showed that the 3D-PT-P/GM scaffolds possessed multilayered structure with interlayer spacing of about 15-80 μm, and the hexagonal micropatterned structures were uniformly distributed on the surface of each layer.
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