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Isolation and Characterization of a Lytic Phage PaTJ Against .
Viruses
November 2024
Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510000, China.
is a major global threat to human health, and phage therapy has emerged as a promising strategy for treating infections caused by multidrug-resistant pathogens. In this study, we isolated and characterized a lytic phage, PaTJ, from wastewater. PaTJ belongs to the phage family , and is featured by short latency (30 min) and large burst size (10 PFU per infected cell).
View Article and Find Full Text PDFSynthesis and Characterization of Two Sparfloxacin Crystalline Salts: Enhancing Solubility and In Vitro Antibacterial Activity of Sparfloxacin.
Pharmaceutics
November 2024
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
: To improve the solubility and permeability of Sparfloxacin (SPX) and enhance its antimicrobial activity in vitro, two unreported pharmaceutical crystalline salts were synthesized and characterized in this paper. One is a hydrated crystal of Sparfloxacin with Pimelic acid (PIA), another is a hydrated crystal of Sparfloxacin with Azelaic acid (AZA), namely, SPX-PIA-HO (2CHFNO·CHO·2HO) and SPX-AZA-HO (4CHFNO·2CHO·5HO). : The structure and purity of two crystalline salts were analyzed using solid-state characterization methods such as single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and infrared spectroscopy.
View Article and Find Full Text PDFEssential Oils Obtained from Sicilian Blanco By-Products: Antibacterial and Allelopathic Activity.
Plants (Basel)
December 2024
Department of Life Science, Health, and Health Professions, University of Rome "Link Campus", 00165 Rome, Italy.
Mandarin, one of the winter fruits commonly used in the preparation of foods and juices, is a fruit native to China and Southeast Asia. In this work, essential oils (EOs) obtained from by-products of the Blanco flavedo of five cultivars present and cultivated within the Botanical Garden of Palermo were chemically and biologically studied: 'Avana' (), 'Tardivo di Ciaculli' (), 'Bombajensis' (), 'Aurantifolia' (), and 'Padre Bernardino' (). The GC and GC-MS analysis performed on all the extracted samples clearly highlighted the notable presence of limonene, a characteristic hydrocarbon monoterpene of EOs of the genus.
View Article and Find Full Text PDFMayan Medicinal Plants and Demonstrate Anti-Infective Properties Against the Priority Antibiotic-Resistant Bacteria and .
Plants (Basel)
December 2024
Unidad Médica de Alta Especialidad, Centro Médico Ignacio García Téllez, Instituto Mexicano del Seguro Social, Mérida 97150, Yucatán, Mexico.
(1) Background: Carbapenem-resistant (CBRAB) and (CBRPA) are critical and high-priority pathogens that require new therapeutic developments. Medicinal plants are valuable pharmaceutical resources. This study explored the anti-infective properties of Mayan plants, , and .
View Article and Find Full Text PDFIn Vitro Antioxidant and Antibacterial Activities of Ethyl Acetate Extracts of Leaves and Five Associated Endophytic Fungi.
Microorganisms
December 2024
Laboratory of Analytic Biochemistry and Biotechnology (LABAB), Department of Biochemistry and Microbiology, Faculty of Biological and Agronomic Sciences, Mouloud Mammeri University, Tizi-Ouzou 15000, Algeria.
The exploration of new pharmacological compounds from endophytic fungi offers infinite possibilities. The aim of this study was to evaluate the antibacterial and antioxidant activities of extracts from the leaves of and five of its endophytic fungi and investigate the chemical diversity of the secondary metabolites produced. Isolated, purified, and molecularly identified endophytes and plant leaves were subjected to ethyl acetate extraction.
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