Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors.

Bioorg Med Chem Lett

Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Nishi 11, Kita 21, Kita-ku, Sapporo 001-0021, Japan.

Published: March 2009

In this Letter, we assessed newly synthesized sphingolipid analogs as ligands for peroxisome proliferator-activated receptor (PPAR)alpha, PPARbeta or PPARgamma, using a dual-luciferase reporter system. We tested 640 sphingolipid analogs for ligand activity. As a result, seven types: A9, B9, C9, C50, F66, G66 and H66, were found to show agonistic activities for PPARs.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.004DOI Listing

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