Objective: To gain insight into the biomechanics of upslope wheelchair stroking by examining the changes in kinematic and electromyographic characteristics of wheelchair propulsion over ramps of different slopes.
Design: Repeated-measures design. Each subject pushed up a wooden ramp (7.3m long) 3 times at self-selected normal and fast speeds for each of these slopes: 0 degrees , 2 degrees , 4 degrees , 6 degrees , 8 degrees , 10 degrees , and 12 degrees .
Setting: A biomechanics laboratory.
Participants: Young men (N=10) with paraplegia.
Interventions: Not applicable.
Main Outcome Measures: Electromyographic activity of extensor carpi radialis, triceps brachii, antero-middle and postero-middle deltoids, pectoralis major, and latissimus dorsi, and stroking kinematics.
Results: Forward lean of the trunk increased as the slope increased. The triceps brachii, antero-middle deltoid, and pectoralis major were more active during the push phase, while the postero-middle deltoid was more active during the recovery phase. Both extensor carpi radialis and latissimus dorsi were active throughout a stroke. Major adjustments in stroking kinematics and significant increases in muscle activity occurred at slopes between 4 degrees and 10 degrees .
Conclusion: In addition to a decrease in stroking speed, the stroking pattern becomes more compact (decreased push angle and relative recovery time, increased stroke frequency) and the trunk becomes more active with increasing slope.
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http://dx.doi.org/10.1016/j.apmr.2008.07.019 | DOI Listing |
Biotechnol J
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School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland.
Adeno-associated virus (AAV) is a versatile viral vector technology that can be engineered for specific functionality in vaccine and gene therapy applications. One of the major challenges in AAV production is the need for a GMP-ready platform-based approach to downstream processing, as this would lead to a standardized method for multiple products. Chromatography has huge potential in AAV purification, as it is a scalable method that would enable manufacturing to a high degree of purity, potency, and consistency.
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January 2025
Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, J.J.Thomson Avenue, Cambridge CB3 0HE, UK.
Benefiting from improved stability due to interlayer van der Waals interactions, few-layer fullerene networks are experimentally more accessible compared to monolayer polymeric C. However, there is a lack of systematic theoretical studies on the material properties of few-layer C networks. Here, we compare the structural, electronic and optical properties of bilayer and monolayer fullerene networks.
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January 2025
Institute for Microbial Systems and Society, Faculty of Science, University of Regina, Regina, Saskatchewan, Canada.
Unlabelled: Antimicrobial resistance (AMR) is a global threat. The identification and characterization of novel resistance genes is integral to AMR surveillance. The (55) gene was originally identified through whole genome sequencing of macrolide-resistant strains of .
View Article and Find Full Text PDFChaos
January 2025
Department of Control Theory, Scientific and Educational Mathematical Center "Mathematics of Future Technologies", Nizhny Novgorod State University, Gagarin Av. 23, Nizhny Novgorod 603022, Russia.
We consider the effect of the emergence of chimera states in a system of coexisting stationary and flying-through in potential particles with an internal degree of freedom determined by the phase. All particles tend to an equilibrium state with a small number of potential wells, which leads to the emergence of a stationary chimera. An increase in the number of potential wells leads to the emergence of particles flying-through along the medium, the phases of which form a moving chimera.
View Article and Find Full Text PDFJ Virol
January 2025
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
The common cold coronaviruses are a source of ongoing morbidity and mortality particularly among elderly and immunocompromised individuals. While cross-reactive immune responses against multiple coronaviruses have been described following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, it remains unclear if these confer any degree of cross-protection against the common cold coronaviruses. A recombinant fowl adenovirus vaccine expressing the SARS-CoV-2 spike protein (FAdV-9-S19) was generated, and protection from SARS-CoV-2 challenge was shown in K18-hACE2 mice.
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