Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
A systemic approach to appraisal of the mechanisms of changes of erythropoiesis biorhythms in stress is suggested. The authors studied the daily and seasonal rhythms of serum erythropoietin (EP) level, the production of erythrocytes (PE), the kinetics of bone marrow erythroid cells, and the activity of lipid peroxidation (LPO) and G-6-PDG in peripheral blood erythrocytes in albino rats. As a stress factor hyperbaric oxygenation initiated LPO acceleration and change of PE circadian rhythm with mesor decrease. Increased production of erythrocytes with reduction of their life span was simultaneously revealed. The differences in acrophases and amplitudes of erythropoiesis values in different seasons are caused by changes of erythroid cell kinetics due to mobilization of terminal erythropoiesis.
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