AI Article Synopsis
- Researchers modeled stimulation and inhibition of erythropoiesis in rats to investigate the role of central macrophages in bone marrow erythroblastic islets (EI) through various biochemical measures.
- The study assessed lysosomal content, pH, acid phosphatase activity, and incorporation of 3H-thymidine into DNA to evaluate macrophage function.
- Findings indicate that the activity of macrophages in EI is influenced by the levels of erythropoiesis, with a sensitivity to erythropoietin observed during EI cultivation.
Article Abstract
Stimulation and inhibition of erythropoiesis were modelled in rats to study the functional condition of central macrophages of the erythroblastic islets (EI) in the bone marrow by determining the total content of lysosomes, pH of lysosomes, activity of acid phosphatase, and 3H-thymidine inclusion in DNA. The properties of the surface charges of the EI cells were judged according to the electrophoretic mobility, the number of acid glycoproteins--according to the staining of the preparations with alcian blue. It is shown that the intensity of erythropoiesis in the EI determines the studied values. Sensitivity of EI macrophages to erythropoietin was demonstrated in EI cultivation.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!