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Extended performance of cognitively demanding tasks induces cognitive fatigue manifested with an overall deterioration of behavioral performance. In particular, long practice with tasks requiring impulse control is typically followed by a decrease in self-control efficiency, leading to performance instability. Here, we show that this is due to changes in activation modalities of key task-related areas occurring if these areas previously underwent intensive use.

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Objective: Sexual assault perpetration is widespread among young men. According to the Confluence Model, hostile masculinity and impersonal sex are trait-level factors associated with sexual assault perpetration likelihood. Additionally, state-level factors, including alcohol intoxication, current emotions, and ability to modulate one's emotions, have been tied to sexual assault perpetration via the I3 Model.

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Mounting evidence suggests hierarchical psychopathology factors underlying psychiatric comorbidity. However, the exact neurobiological characterizations of these multilevel factors remain elusive. In this study, leveraging the brain-behavior predictive framework with a 10-year longitudinal imaging-genetic cohort (IMAGEN, ages 14, 19 and 23,  = 1,750), we constructed two neural factors underlying externalizing and internalizing symptoms, which were reproducible across six clinical and population-based datasets (ABCD, STRATIFY/ ESTRA, ABIDE II, ADHD-200 and XiNan, from age 10 to age 36,  = 3,765).

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