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Quality of life measures for people following stroke: a structured content review.
Qual Life Res
December 2024
School of Physical Therapy, University of Western Ontario, London, Canada.
Introduction: Patient Reported Outcome Measures (PROMs) are used widely to collect patient perspectives on their Health-Related Quality of Life (HRQoL) after stroke. Existing reviews on PROMs typically report the psychometric properties but rarely focus on the content validity. We performed a structured review of the content of items of stroke-specific HRQoL outcomes.
View Article and Find Full Text PDFCompeting Photocleavage on Boron and at the -Position in BODIPY Photocages.
J Org Chem
December 2024
Department of Organic Chemistry and Biochemistry, Rud̵er Bošković Institute, Bijenička Cesta 54, Zagreb 10 000, Croatia.
BODIPY photocages (photocleavable protective groups) have stirred interest because they can release biologically active cargo upon visible light excitation. We conducted combined theoretical and experimental investigations on selected BODIPY photocages to elucidate the mechanism of the competing photocleavage at the boron and -position. Based on the computations, the former reaction involves elongation of the B-C bond, yielding a tight borenium cation and methyl anion.
View Article and Find Full Text PDFThe impact of cognitive bias about infectious diseases on social well-being.
Front Epidemiol
December 2024
Mathematical Institute, Faculty of Mathematics & Natural Sciences, University of Koblenz, Koblenz, Germany.
Introduction: We investigate the relationship between bias, that is, cognitive distortions about the severity of infectious disease and social well-being.
Materials And Methods: First, we establish empirically the existence of bias and analyze some of its causes; specifically, during the COVID-19 pandemic. Second, we derive an integrated economic-epidemiological differential equation model from an agent-based model that combines myopic rational choice with infectious disease dynamics.
IN SILICO BASED RE-ENGINEERING OF A COMPUTATIONALLY DESIGNED BIOSENSOR WITH ALTERED SIGNALLING MODE AND IMPROVED DYNAMIC RANGE.
Arch Biochem Biophys
December 2024
Alberta RNA Research and Training Institute (ARRTI), University of Lethbridge, Lethbridge, AB, Canada; Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada.
A current challenge in the rational design of biomolecular sensors is the ability to custom design binding affinities and detection mode in silico. To this end, we re-engineered a previously reported computationally-designed fluorescent maltooligosaccharide (MOS)-detecting biosensor to both alter its ligand-binding affinity and to analyse the underlying sensing mechanism. The dynamic range of the biosensor was expanded through the computer aided introduction of a series of amino acid substitutions in the starting protein scaffold (MalX from Streptococcus pneumoniae), which generated a biosensor set with binding affinities spanning over five orders of magnitude.
View Article and Find Full Text PDFBifunctional Design of Ferroelectric-Order and Band-Engineering in Cu:KTN Crystal for Extended Self-Powered Photoelectric Response.
Adv Sci (Weinh)
December 2024
State Key Laboratory of Crystal Materials and Institute of Crystal Materials, Shandong University, Jinan, 250100, China.
Photoelectric conversion in ferroelectric crystals can support many important applications in modern on-chip technology, but suffering from two problems, low responsive current and narrow responsive range. Especially, wide-gap ferroelectric oxides are only active at short-wavelength ultraviolet region with weak photocurrent at nanoampere levels. Here, a bifunctional design strategy of ferroelectric-order and electronic-band to improve the photocurrent and extend the responsive range simultaneously, is proposed.
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