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Nanomaterials that can circulate in the body hold great potential to diagnose and treat disease. For such applications, it is important that the nanomaterials be harmlessly eliminated from the body in a reasonable period of time after they carry out their diagnostic or therapeutic function. Despite efforts to improve their targeting efficiency, significant quantities of systemically administered nanomaterials are cleared by the mononuclear phagocytic system before finding their targets, increasing the likelihood of unintended acute or chronic toxicity. However, there has been little effort to engineer the self-destruction of errant nanoparticles into non-toxic, systemically eliminated products. Here, we present luminescent porous silicon nanoparticles (LPSiNPs) that can carry a drug payload and of which the intrinsic near-infrared photoluminescence enables monitoring of both accumulation and degradation in vivo. Furthermore, in contrast to most optically active nanomaterials (carbon nanotubes, gold nanoparticles and quantum dots), LPSiNPs self-destruct in a mouse model into renally cleared components in a relatively short period of time with no evidence of toxicity. As a preliminary in vivo application, we demonstrate tumour imaging using dextran-coated LPSiNPs (D-LPSiNPs). These results demonstrate a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications.
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http://dx.doi.org/10.1038/nmat2398 | DOI Listing |
Mikrochim Acta
December 2024
Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
A novel electrochemiluminescence (ECL) biosensor was developed for the ultrasensitive detection of miRNA-155, based on the synergistic combination of multifunctional nanomaterials. The biosensor employed a conductive metal-organic framework (MOF), Ni(HAB) (HAB = hexaaminobenzene), as the substrate material. The unique π-electron conjugated structure of Ni(HAB) endowed the biosensor with excellent electron transport properties, significantly enhancing its sensitivity.
View Article and Find Full Text PDFInorg Chem
December 2024
School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
Luminescent silver clusters that are confined inside porous zeolites have attracted great research interest due to the combined advantages of high quantum yield, tunable emission, excellent chemical stability, and desirable adoption ability of this micronano-composite. In this research, a series of Ag-exchanged R-LTA/Ag (R = Li, Na, K) zeolites were synthesized, in which the silver clusters showed blue-shifted excitation in the UV region, red-shifted emission in the visible region, and decreased emission intensity when taking Li, Na, and K as the extra-framework cations, respectively. The [Ag(HO)R-sod] ( = 2, 4; R = Li, Na, K) structures were constructed, and the TD-DFT method was further carried out to study the influence of extra-framework cations on the luminescence performance of [Ag] clusters, in which the substitution of Al for Si and the reasonable hydrate levels were both taken into consideration.
View Article and Find Full Text PDFTalanta
December 2024
Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China. Electronic address:
To address the health risks posed by microplastics (MPs), this work developed a poly-l-cysteine (poly-L-cys)-based electrochemiluminescence (ECL) sensor for detecting MPs in water environments. The porous structure of poly-L-cys film can regulate the generation of copper nanoclusters (Cu NCs) in the pores, effectively limiting the migration and aggregation of nanopaticles. In addition, poly-L-cys film also acted as co-reactant promoters, promoting electron transfer and effectively enhancing ECL signal of Cu NCs.
View Article and Find Full Text PDFInorg Chem
December 2024
Center of Advanced Analysis and Gene Sequencing, Key Laboratory of Molecular Sensing and Harmful Substances Detection Technology, Zhengzhou University, Kexue Avenue 100, Zhengzhou, Henan 450001, P. R. China.
The enantioselective performance of porous chiral metal-organic frameworks (CMOFs) is closely related to the pore size and uniformity of easily accessible active sites. The chiral recognition efficiency of microporous CMOFs is hindered by the restricted diffusion of the guest. Hierarchical porous chiral CMOFs with multiple pore size regimes ranging from micropores to macropores have emerged as potential candidates in chiral separation applications.
View Article and Find Full Text PDFCarbohydr Polym
February 2025
Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Taizhou University, Zhejiang, Taizhou 318000, China. Electronic address:
Using new materials to improve detection accuracy and efficiency is important to broaden the application of immunoassay sensors. Among numerous materials for improving sensors, chitosan, as a natural polysaccharide, has excellent biocompatibility, mechanical adjustability, stimulation sensitivity and porous structure, which holds significant potential for enhancing the performance of immunoassay sensors. However, at present, there are few systematic reviews on the application of chitosan in immune sensors.
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