AI Article Synopsis
- The study aimed to explore how CD40 ligand and P-selectin relate to lower cardiovascular disease rates in individuals with Gilbert's syndrome (GS).
- Significant reductions in soluble CD40 ligand (sCD40L) and high sensitive C-reactive protein (hs-CRP) levels were observed in GS patients compared to healthy participants, indicating potential protective factors against cardiovascular issues.
- While sP-selectin levels were also lower in GS, this difference wasn't statistically significant, and there's no correlation between sCD40L, sP-selectin, and hs-CRP levels.
Article Abstract
Objective: To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).
Design And Methods: The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (n=25) and compared to healthy controls (n=53).
Results: sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33+/-0.27 vs 0.71+/-0.37 ng/mL, p<0.001 and 0.51+/-0.45 vs 1.16+/-1.31 mg/L, p=0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (r=-0.5, p<0.001 and r=-0.34, p=0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (p=0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP.
Conclusion: These novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS.
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| http://dx.doi.org/10.1016/j.clinbiochem.2009.02.005 | DOI Listing |
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