Gastric and small-bowel dysfunction can include gastroparesis, functional dyspepsia, and even irritable bowel syndrome. Patients with symptoms suggesting these disorders are commonly encountered by a variety of physicians, especially gastroenterologists. In most patients, the physical examination and upper endoscopy are normal, and thus symptoms are suggested to be from a motility disorder or a functional gastrointestinal disorder. Further evaluation directed at evaluating the stomach and small-bowel motility may help the clinician to arrive at a correct diagnosis enabling proper treatment of the patient. This article covers several tests that are used to evaluate gastric and small-bowel motility in patients, either in clinical evaluation or in clinical research.
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http://dx.doi.org/10.1016/j.giec.2008.12.003 | DOI Listing |
Cell Calcium
December 2024
Department of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, 89557, USA. Electronic address:
Interstitial cells of Cajal in the plane of the myenteric plexus (ICC-MY) serve as electrical pacemakers in the stomach and small intestine. A similar population of cells is found in the colon, but these cells do not appear to generate regular slow wave potentials, as characteristic in more proximal gut regions. Ca handling mechanisms in ICC-MY of the mouse proximal colon were studied using confocal imaging of muscles from animals expressing GCaMP6f exclusively in ICC.
View Article and Find Full Text PDFNeurogastroenterol Motil
December 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Introduction: Gastrointestinal (GI) magnetic resonance imaging (MRI) enables simultaneous assessment of gastric peristalsis, emptying, and intestinal filling and transit. However, GI MRI in animals typically requires anesthesia, which complicates physiology and confounds interpretation and translation to humans. This study aimed to establish GI MRI in conscious rats, and for the first time, characterize GI motor functions in awake versus anesthetized conditions.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Background: () may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the correlation and co-pathogenic pathways between and IBD.
View Article and Find Full Text PDFGut Microbes
December 2025
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
How the gut microbiota and immune system maintain intestinal homeostasis in concert with the enteric nervous system (ENS) remains incompletely understood. To address this gap, we assessed small intestinal transit, enteric neuronal density, enteric neurogenesis, intestinal microbiota, immune cell populations and cytokines in wildtype and T-cell deficient germ-free mice colonized with specific pathogen-free (SPF) microbiota, conventionally raised SPF and segmented filamentous bacteria (SFB)-monocolonized mice. SPF microbiota increased small intestinal transit in a T cell-dependent manner.
View Article and Find Full Text PDFClin Pharmacol Ther
December 2024
Nottingham NIHR Research Centre, University of Nottingham, Nottingham, UK.
Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single dose of Bisacodyl 5 mg while the second dosed daily for 3 consecutive days.
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