Part 1 documents and discusses a letter, written in 1920 by Rank to Abraham, telling him of two Frankfurt neurologists, Kurt Goldstein and Walther Riese, who had applied for membership in the IPA, and adding recommendations of how to deal with them. Part 2 is concerned with a report, given by Barbara Lantos of some disparaging remarks about psychoanalysis made by Albert Moll which led Freud to withdraw his public support of the 1st International Congress of Sexual Research in 1926. It also refers to an earlier discussion in Berlin where Moll already had made the same critical comments.
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Nutrients
June 2024
Department of Obstetrics and Gynaecology, National University Hospital, Singapore 119074, Singapore.
We previously reported that a combined -inositol, probiotics, and enriched micronutrient supplement (intervention) taken preconception and in pregnancy reduced postpartum blood loss (PBL) and major postpartum hemorrhage compared with a standard micronutrient supplement (control), as secondary outcomes of the NiPPeR trial. This study aimed to identify the intervention components that may contribute to this effect. Associations of plasma concentrations of -inositol and vitamins B2, B6, B12, and D at preconception (before and after supplementation), early (~7-weeks), and late pregnancy (~28-weeks) with PBL were assessed by multiple linear regression, adjusting for site, ethnicity, preconception BMI, parity, and previous cesarean section.
View Article and Find Full Text PDFSci Rep
May 2024
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting of a baseline model, where prediction is based on demographic and clinical variables only, and a genetic model, where we also include PRSs. We evaluate the use of a linear versus a non-linear model at both the baseline and the genetic model levels and assess the improvement in performance when incorporating multiple PRSs.
View Article and Find Full Text PDFJ Gerontol A Biol Sci Med Sci
July 2024
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Background: Motoric Cognitive Risk (MCR) syndrome, a predementia syndrome characterized by cognitive complaints and slow gait, may have an underlying vascular etiology. Elevated blood levels of homocysteine, a known vascular risk factor, have been linked to physical and cognitive decline in older adults, though the relationship with MCR is unknown. We aimed to identify the association between homocysteine and MCR risk.
View Article and Find Full Text PDFStroke
March 2024
Department of Neurology (Mariam Ali, L.D., I.R.v.d.W., N.D.K., M.J.H.W., T.T.M.N.), Leiden University Medical Center, the Netherlands.
Background: Differences in clinical presentation of acute ischemic stroke between men and women may affect prehospital identification of anterior circulation large vessel occlusion (aLVO). We assessed sex differences in diagnostic performance of 8 prehospital scales to detect aLVO.
Methods: We analyzed pooled individual patient data from 2 prospective cohort studies (LPSS [Leiden Prehospital Stroke Study] and PRESTO [Prehospital Triage of Patients With Suspected Stroke Study]) conducted in the Netherlands between 2018 and 2019, including consecutive patients ≥18 years suspected of acute stroke who presented within 6 hours after symptom onset.
medRxiv
December 2023
Department of Medicine, Brigham and Women's Hospital, Boston, MA.
We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting of a baseline model, where prediction is based on demographic and clinical variables only, and a genetic model, where we also include PRSs. We evaluate the use of a linear versus a non-linear model at both the baseline and the genetic model levels and assess the improvement in performance when incorporating multiple PRSs.
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