By rendering obsolete the theoretical opposition of nature and culture, the study of the human genome has given rise to fresh networks among anthropologists and other scholars. These developments, in turn, invite a refashioning of anthropology. Because genomic studies are directly concerned with the constitution of personhood, they must engage with local notions of personhood and belonging, thus undermining the distinction between experts and laypersons and demonstrating the need for new frameworks for collaboration between anthropologists and their subjects. These trends are illustrated by research in Nunavut (Canada) and Greenland, in particular an examination of the similarities and differences between modern gene talk about the constitution of the individual and "Inuit epigenetics"--local notions of naming, subjectivity, and relatedness.
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Nature
January 2025
Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Nature
January 2025
Department of Genetics, Trinity College Dublin, Dublin, Ireland.
Roman writers found the relative empowerment of Celtic women remarkable. In southern Britain, the Late Iron Age Durotriges tribe often buried women with substantial grave goods. Here we analyse 57 ancient genomes from Durotrigian burial sites and find an extended kin group centred around a single maternal lineage, with unrelated (presumably inward migrating) burials being predominantly male.
View Article and Find Full Text PDFNature
January 2025
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
After a long-distance migration, Avars with Eastern Asian ancestry arrived in Eastern Central Europe in 567 to 568 CE and encountered groups with very different European ancestry. We used ancient genome-wide data of 722 individuals and fine-grained interdisciplinary analysis of large seventh- to eighth-century CE neighbouring cemeteries south of Vienna (Austria) to address the centuries-long impact of this encounter. We found that even 200 years after immigration, the ancestry at one site (Leobersdorf) remained dominantly East Asian-like, whereas the other site (Mödling) shows local, European-like ancestry.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2024
College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Utilizing network pharmacology and molecular docking, we evaluated the possible pharmacological mechanism of Danggui Sini Decoction (DGSND) for treating erectile dysfunction (ED). DGSND's chemical components and targets were found utilizing the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Disease-related genes associated with ED were identified through GeneCards, OMIM, TTD, DrugBank, and DisGeNET databases.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Primate Behavioral Ecology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.
Biological relatedness is a key consideration in studies of behavior, population structure, and trait evolution. Except for parent-offspring dyads, pedigrees capture relatedness imperfectly. The number and length of identical-by-descent DNA segments (IBD) yield the most precise relatedness estimates.
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