No one is in a better position to get an incoming CEO up to speed than his or her predecessor, whose insights and accumulated wisdom are uniquely valuable during the transition and even beyond. The outgoing leader can provide information about the expectations of high-ranking employees; short-term opportunities ripe for harvesting; how the board and others perceive the newcomer's reputation or personal brand; the strengths and foibles of internal allies and external partners; organizational bench strength; and the wisdom that comes from experience well reflected upon. Organizations and their shareholders don't want intellectual capital like this to simply evaporate, which is why nearly every multinational corporation makes ongoing consultation a requirement in severance contracts and pays handsomely for it. Nevertheless, candid, in-depth discussions between outgoing and incoming CEOs rarely take place. Friel, formerly the chairman and CEO of Heidrick & Struggles, and Duboff, the CEO and a cofounder of HawkPartners, conducted numerous interviews with people who had been through at least one CEO transition to find out why those discussions didn't happen as a matter of course and how best to draw on the knowledge of a departing leader. They clearly outline the steps that organizations can take, such as making golden parachutes contingent on debriefing conversations, having HR arrange the meetings to dispel any awkwardness, and creating a thorough agenda. And they advise the two executives to meet as equals, share the "first 90 days plan," and speak consistently about the past and the future--to the media as well as to stakeholders. Much of an outgoing CEO's knowledge will be lost unless a conscious effort is made to capture it. As the average tenure of chief executives shrinks, it becomes increasingly imperative that they get off to a strong start.
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Int J Biol Macromol
January 2025
Department of cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing 100081, PR China.
Periodontitis is a chronic inflammatory condition mainly caused by the interaction between the host immune system and periodontal tissue pathogens, and may lead to consequences, such as alveolar bone defects and tooth loss. Incomplete bacterial removal, persistent inflammation and high reactive oxygen species (ROS) environment are the main challenges for periodontal tissue repair and alveolar bone regeneration. In this study, an injectable composite microgel (Gelatin methacryloyl-Phenylboronic acid/Hydroxyadamantane, GPH) loaded with antimicrobial peptide (AMP) and cerium dioxide (CeO) microspheres was developed to achieve a synergistic function of bacteriostasis, immunomodulation, and ROS removal.
View Article and Find Full Text PDFAnal Chem
January 2025
School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, P. R. China.
Organophosphorus pesticides (OPs) are widely used in agricultural production, posing a great threat to human health and the environment. Given that different OPs present different toxicology and toxicities, identifying individual pesticide residues becomes important for assessing food safety and environmental implications. In this work, a kinetics difference-driven analyte hydrolysis strategy is proposed for the first time and validated to identify -nitrophenyl pesticides by developing an organophosphorus hydrolase-like nanozyme-coded sensor array.
View Article and Find Full Text PDFChem Eng J
January 2025
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, China.
Immune checkpoint blockade (ICB) therapy has been extensively integrated into cancer clinical management. However, its overall response rate is limited due to the stagnating cancer-immunity cycle (CIC) caused by the immunosuppressive tumor microenvironment (TME). Here, a multi-pronged nanomedicine, defined as LCCS, was constructed by the self-assembly of lactate oxidase, catalase, chlorin e6, and sorafenib.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China; Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China. Electronic address:
The controlled release active packaging film represents a novel technology that always can effectively slow down the release of active agents, extending their efficacy. Mucorracemosus Fresenius (MF) mycelium was prepared and used as an adsorption carrier to load clove essential oil (CEO). The CEO/MF complexes were incorporated into the starch/polyvinyl alcohol (Starch/PVA) matrix to develop active films.
View Article and Find Full Text PDFAnal Chim Acta
January 2025
State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130000, PR China. Electronic address:
Nitrite is widely used as a food additive, and it is of great significance to realize accurate detection of nitrite for food safety. Electrochemical technique is characterized by simple operation and portability, which enables rapid and accurate detection. The key factors affecting the nitrite detection performance are the electrocatalytic activity and interfacial electron transfer efficiency of the electrode.
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