It was studied the effects of alimentary deprivation during 28 days on functional state and physiological regeneration of liver. In 3 and 9-month rats it was shown an increase in the amount of hepatocytes per unit of area of tissue, their nucleis were hypertrophied, the area of cytoplasm was decreased, the number of binucleitic hepatocytes in 9-month animals was increased. Thus, our study suggests that a short-term 40% food limitation stimulates physiological regeneration of liver parenchyma.
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