A 32-year-old Japanese woman admitted November 1 for a 4-day fever and who had traveled in India October 14-22 was found to have no abnormal findings except for fever and luekocytopenia and thrombocytopenia. Negative rapid-test anti-dengue virus IgM antibody findings, however, became positive on hospital 2, with hemophagocytic cells found in the bone marrow, yielding a definitive diagnosis of dengue fever with viral-associated hemophagocytic syndrome. Some such cases with hemophagocytic syndrome have been reported in patients with sever dengue fever, but the rarity of the need for bone marrow examination means that it is unknown whether hemophagocytic syndrome occurs in mild dengue fever or whether our case was unusual.
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http://dx.doi.org/10.11150/kansenshogakuzasshi.83.60 | DOI Listing |
Diagn Microbiol Infect Dis
January 2025
Department of Anatomy, Jajati Keshari Medical College and Hospital, Jajpur, Odisha, India.
Dengue virus (DENV) is an important arthropod-borne viral disease, with four antigenically and genetically diverse serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). Timely and accurate diagnosis of dengue virus serotypes is crucial for the management of outbreaks. This study focussed on the development of a RT-PCR based lateral flow strip assay to detect DENV serotypes in a dual detection manner without using gel electrophoresis.
View Article and Find Full Text PDFNat Microbiol
January 2025
Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
T cells have been identified as correlates of protection in viral infections. However, the level of vaccine-induced T cells needed and the extent to which they alone can control acute viral infection in humans remain uncertain. Here we conducted a double-blind, randomized controlled trial involving vaccination and challenge in 33 adult human volunteers, using the live-attenuated yellow fever (YF17D) and chimeric Japanese encephalitis-YF17D (JE/YF17D) vaccines.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Laboratorio de Ingeniería Genética y Biología Celular y Molecular-Área de virus de insectos, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Quilmes, Buenos Aires, Argentina.
Mosquitoes are the primary vectors of arthropod-borne pathogens. Aedes aegypti is one of the most widespread mosquito species worldwide, responsible for transmitting diseases such as Dengue, Zika, and Chikungunya, among other medically significant viruses. Characterizing the array of viruses circulating in mosquitoes, particularly in Aedes aegypti, is a crucial tool for detecting and developing novel strategies to prevent arbovirus outbreaks.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Sustainable Sciences Institute, Managua, Nicaragua.
Background: Dengue virus, a major global health threat, consists of four serotypes (DENV1-4) that cause a range of clinical manifestations from mild to severe and potentially fatal disease.
Methods: This study, based on 19 years of data from the Pediatric Dengue Cohort Study and Pediatric Dengue Hospital-based Study in Managua, Nicaragua, investigates the relationship of serotype and immune status with dengue severity. Dengue cases were confirmed by molecular, serological, and/or virological methods, and study participants 6 months to 17 years old were followed during their hospital stay or as ambulatory patients.
PLoS Negl Trop Dis
January 2025
Department of Infectious Diseases, Children's Hospital 2, Ho Chi Minh City, Vietnam.
Background: Severe respiratory distress and acute kidney injury (AKI) are key factors leading to poor outcomes in patients with dengue shock syndrome (DSS). There is still limited data on how much resuscitated fluid and the specific ratios of intravenous fluid types contribute to the development of severe respiratory distress necessitating mechanical ventilation (MV) and AKI in children with DSS.
Methodology/principal Findings: This retrospective study was conducted at a tertiary pediatric hospital in Vietnam between 2013 and 2022.
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