AI Article Synopsis
- The synthesis of 1,2-oxazetidin-3-ones involves using chiral catalysts and specific starting materials to achieve good regioselectivity and enantioselectivity in cycloadditions of ketenes with nitroso compounds.
- The resulting products are not only potentially bioactive target molecules but can also be converted into other important compounds.
- These compounds include alpha-hydroxycarboxylic acid derivatives, which have further applications in various fields.
Article Abstract
The appropriate choice of chiral catalyst and starting materials leads to the synthesis of 1,2-oxazetidin-3-ones by cycloadditions of ketenes with nitroso compounds with very good regioselectivity and enantioselectivity. In addition to serving as potentially bioactive target molecules, the products can be transformed into other important classes of compounds, such as alpha-hydroxycarboxylic acid derivatives.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728616 | PMC |
| http://dx.doi.org/10.1002/anie.200805805 | DOI Listing |
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