A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, beta-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254017 | PMC |
| http://dx.doi.org/10.3390/molecules14020763 | DOI Listing |
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