Xeroderma pigmentosum is a rare and severe photodermatitis without cure. Skin cancers are inevitable and give rise to iterative skin resections often mutilating especially in the face. We report the case of two sisters suffering from severe forms of xeroderma pigmentosum. Given the rapid emergence of multicancerous lesions, we opted for a radical approach entailing successively all aesthetic sub-units of the face. The reconstruction uses an original method used initially in the great burned: the artificial dermis. This simple method, providing a quality sub-soil, has helped us in these two complex cases to ensure coverage of a large defect providing a tissue recovery of excellent trophic and aesthetics quality. Thanks to this treatment strategy, we were able to significantly delay the development of this disease. With a retreat of 35 months, the quality of reconstruction by artificial dermis is considered to be satisfactory for its elasticity and its trophicity.
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