AI Article Synopsis
- Daughter cells must maintain the same gene expression patterns as their parent cells to preserve phenotypes, a process made complicated by the halt of transcription during mitosis.
- Mitosis involves the compaction of DNA and the dissociation of binding factors, which poses a challenge for understanding how gene expression memories are transferred.
- Gene bookmarking is the mechanism that allows active gene expression patterns to be remembered during mitosis, with recent studies highlighting the role of the transcription factor TBP in this process.
Article Abstract
In order for cell lineages to be maintained, daughter cells must have the same patterns of gene expression as the cells from which they were divided so that they can have the same phenotypes. However, during mitosis transcription ceases, chromosomal DNA is compacted, and most sequence-specific binding factors dissociate from DNA, making it difficult to understand how the "memory" of gene expression patterns is remembered and propagated to daughter cells. The process of remembering patterns of active gene expression during mitosis for transmission to daughter cells is called gene bookmarking. Here we discuss current knowledge concerning the factors and mechanisms involved in mediating gene bookmarking, including recent results on the mechanism by which the general transcription factor TBP participates in the mitotic bookmarking of formerly active genes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748302 | PMC |
| http://dx.doi.org/10.4161/cc.8.6.7849 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!