AI Article Synopsis
- A study was conducted to determine the impact of combining plasma exchange (PE) with hemofiltration (HF) on patients with liver failure, involving 77 patients assigned to either PE+HF, PE alone, or a control group without treatment.
- The results indicated significant improvements in liver function markers and a higher survival rate (68.4%) in the PE+HF group compared to the control group (29.3%).
- The combination treatment also showed better recovery rates in patients with hepatic encephalopathy and was more effective in correcting electrolyte and acid-base imbalances than PE alone.*
Article Abstract
Objective: To investigate the effect of plasma exchange (PE) combined with hemofiltration (HF) on liver failure.
Methods: Seventy-seven inpatients with liver failure admitted during January 2006 to August 2007 were randomly assigned to receive PE combined with HF (PE+HF group, 38 cases), or PE alone (PE group, 39 cases). Forty-one inpatients with liver failure who had not received artificial liver support treatment were assigned to serve as control group. The survival rates and biochemical parameters of three groups were compared.
Results: There was no significant difference in biochemical parameters before treatment among three groups. Compared with pre-treatment values, albumin (Alb), cholinesterase (ChE) and prothrombin activity (PTA) of both PE group and PE+HF group were significantly increased after treatment, and total bilirubin (TBIL), alanine transaminase (ALT), aspartate transaminase (AST) of both PE group and PE+HF group were significantly decreased after treatment (P<0.05 or P<0.01). The survival rate of PE group, PE+HF group and control group was 48.7% (19/39), 68.4% (26/38), and 29.3% (12/41) respectively. The survival rate of PE+HF group was significantly higher than that of control group (chi(2)=12.11, P<0.01). The rate of recovery of consciousness of patients with hepatic encephalopathy in PE+HF group was higher than that of PE group (42.8% vs. 0, P<0.05). Compared with PE alone, the result was better when it was combined with HF in correction of electrolyte disturbance and acid-base imbalance (19/23 vs. 0/21, P<0.05).
Conclusion: Treatment of liver failure by PE combined with HF is safe and effective, and its efficacy is higher than PE alone.
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