AI Article Synopsis
- The study examined the role of cardiac troponin T (cTnT) levels measured on the third morning after a ST-segment elevation myocardial infarction (STEMI) in predicting the size of the heart attack and left ventricular function.
- Linear regression analysis indicated a strong correlation between cTnT levels and infarct size, while a weaker, inverse relationship existed between cTnT levels and left ventricular ejection fraction (LVEF).
- The findings suggest that cTnT measurements may help assess the extent of heart damage and could be useful in identifying patients at risk for decreased heart function.
Article Abstract
Objectives: The evaluation of infarct size and left ventricular function after acute myocardial infarction is important for predicting the subsequent clinical course. This assessment can be achieved by non-invasive imaging methods, but biochemical assays are frequently used as an alternative. We investigated the ability of a single measurement of cardiac troponin T (cTnT) the third morning after onset of ST-segment elevation myocardial infarction (STEMI) to predict infarct size and left ventricular ejection fraction (LVEF).
Methods: The study population consisted of 103 patients with their first STEMI treated with thrombolysis. Blood samples for determination of cTnT were drawn the third morning after onset of symptoms. Infarct size and LVEF were assessed by magnetic resonance imaging 3 months later.
Results: Linear regression analysis showed a strong, significant correlation between third-day cTnT and infarct size at 3 months (r = 0.84, p < 0.0001). A significant but inverse and weaker correlation was obtained between third-day cTnT and LVEF (r = -0.63, p < 0.0001). Adjusting for age, gender, infarct location and medication changed the results marginally.
Conclusions: A single cTnT value the third morning after onset of STEMI predicted the final infarct size in this group of patients with their first STEMI, and might be useful for ruling out impaired LVEF.
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| http://dx.doi.org/10.1159/000201991 | DOI Listing |
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