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Thyroid dysgenesis associated with dwarfism, osteoporosis and spontaneous fractures in a goat.
J Comp Pathol
August 2024
Departamento de Cínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
An 11-month-old female Saanen goat, weighing 12.7 kg, was taken to the Veterinary Hospital of the Federal University of Minas Gerais because of sternal recumbency. On clinical examination, the animal was much smaller than expected and had hair similar to that of puppies and areas of hyperpigmentation on the head and dorsocervical and dorsothoracic cranial regions.
View Article and Find Full Text PDFKorean Black Goat Extract Exerts Estrogen-like Osteoprotective Effects by Stimulating Osteoblast Differentiation in MC3T3-E1 Cells and Suppressing Osteoclastogenesis in RAW 264.7 Cells.
Int J Mol Sci
June 2024
Hanbangbio Inc., Yongin-si 17104, Gyeonggi-do, Republic of Korea.
Postmenopausal osteoporosis, characterized by an imbalance between osteoclast-mediated bone resorption and osteoblast-driven bone formation, presents substantial health implications. In this study, we investigated the role of black goat extract (BGE), derived from a domesticated native Korean goat, estrogen-like activity, and osteoprotective effects in vitro. BGE's mineral and fatty acid compositions were analyzed via the ICP-AES method and gas chromatography-mass spectrometry, respectively.
View Article and Find Full Text PDFImpact of Aspiration Percutaneous Vertebroplasty in Reducing Bone Cement Leakage and Enhancing Distribution-An Ex Vivo Study in Goat Vertebrae.
Bioengineering (Basel)
July 2023
Institute of Biomedical Engineering, National Yang-Ming Chiao-Tung University, Taipei 11221, Taiwan.
Article Synopsis
- Osteoporosis-induced vertebral compression fractures (OVCF) are common in people over 50, especially menopausal women, and are treated with techniques like vertebroplasty.
- A new aspiration technique (APV) aims to reduce the risk of bone cement leakage during the procedure, which can lead to serious complications.
- Tests on Nubian goats showed that APV significantly lowers the leakage rate (13% vs. 53%) and provides better cement distribution compared to traditional vertebroplasty.
Alendronate-Decorated Nanoparticles as Bone-Targeted Alendronate Carriers for Potential Osteoporosis Treatment.
ACS Appl Bio Mater
June 2021
Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China.
Osteoporosis is a skeletal disorder characterized by a low bone mass and density. Alendronate (Alen), a second-generation bisphosphonate drug, was indicated as the first-line regimen for the treatment of osteoporosis. However, the use of Alen has been limited due to its low bioavailability and gastrointestinal side effects.
View Article and Find Full Text PDFThe amelioration of T2DM rat femoral bone achieved by anti-osteoporosis of caprine CSN1S2 protein through bone morphogenetic protein signaling pathway.
Acta Biochim Pol
May 2021
Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
We investigated the potential anti-glycation and anti-osteoporosis properties of Caprine milk CSN1S2 protein on the serum AGEs and sRAGE level, osteogenic factors expressions, femoral bone mesostructure, histomorphometry, and hydroxyapatite crystals changes in T2DM rats. Varying doses of Caprine milk CSN1S2 protein (0, 375, 750, and 1500 mg/kg BW) were used to treat the control and T2DM rats. We measured AGEs and sRAGE level; RUNX2, OSX, BMP2, and Caspase-3 expressions in rats using ELISA and immunohistochemistry, respectively.
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