AI Article Synopsis
- SigH is a key regulator of a transcriptional network in mycobacteria, specifically responding to heat and oxidative stress.
- Mycobacterium smegmatis contains seven sigH paralogs in its genome.
- Analysis using real-time reverse transcriptase PCR reveals that sigH paralogs are expressed differently depending on growth stages and stress conditions, with sigH1, sigH4, sigH5, sigH6, and sigH7 showing significant increases during specific stresses.
Article Abstract
SigH regulates a transcriptional network that responds to heat and oxidative stress in mycobacteria. Seven sigH paralogs are reported to exist in the Mycobacterium smegmatis genome. A comprehensive real-time reverse transcriptase PCR analysis during different stages of growth and upon exposure to various stress conditions and antimycobacterial compounds showed differential expression of sigH paralogs during stationary phase and severalfold increases in the levels of transcription of sigH1, sigH4, sigH5, sigH6, and sigH7 under specific stress conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668427 | PMC |
| http://dx.doi.org/10.1128/JB.01773-08 | DOI Listing |
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Differential expression of sigH paralogs during growth and under different stress conditions in Mycobacterium smegmatis.
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Article Synopsis
- SigH is a key regulator of a transcriptional network in mycobacteria, specifically responding to heat and oxidative stress.
- Mycobacterium smegmatis contains seven sigH paralogs in its genome.
- Analysis using real-time reverse transcriptase PCR reveals that sigH paralogs are expressed differently depending on growth stages and stress conditions, with sigH1, sigH4, sigH5, sigH6, and sigH7 showing significant increases during specific stresses.
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