Synthesis of highly deuterium-labeled (R)-K-13675, PPAR alpha agonist, for use as an internal standard for low-level quantification of drugs in plasma.

Bioorg Med Chem

Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co, Ltd, Higashimurayama, Tokyo, Japan.

Published: March 2009

Two highly deuterium-labeled compounds, (R)-K-13675-d(11) and (R)-K-13675-d(7), were prepared for use as internal standards for low-level quantification of plasma drugs by LC/MS/MS. We successfully demonstrated their utility in pharmacokinetic studies for sensitive and precise drug quantification.

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http://dx.doi.org/10.1016/j.bmc.2009.01.049DOI Listing

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