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Reprogramming canine cryopreserved hepatocytes to hepatic progenitor cells using small molecule compounds.
Regen Ther
June 2024
Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Sagamihara City, Kanagawa, Japan.
Introduction: Exploring techniques for differentiating and culturing canine hepatocytes serves as a means to establish systems for liver transplantation and drug metabolism testing. However, establishing consistent methods for culturing stable hepatocytes remains a challenge. Recently, several investigations have shown the reprogramming of mature hepatocytes into hepatic progenitor cells by applying specific small molecule compounds, including Y-27632, (a ROCK inhibitor), A-83-01 (a TGFβ inhibitor), and CHIR99021 (a GSK3 inhibitor) (termed YAC) in rat, mouse, and humans, respectively.
View Article and Find Full Text PDFA Rare Case of Primary Hepatic Undifferentiated Pleomorphic Sarcoma: Exploring Cancer-related Gene Mutations.
Intern Med
November 2024
Division of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Hepatic undifferentiated pleomorphic sarcoma (UPS) is a rare malignant mesenchymal tumor with unclear cancer-related genetic mutations. In a 60-year-old Japanese woman with a rapidly growing, inoperable hepatic UPS, a genetic mutation analysis revealed KRAS and TP53 mutations. Despite initiating hepatic arterial infusion chemotherapy, the tumor continued to grow, and the patient's poor performance status complicated the transition to a phase I KRAS mutation drug trial, leading to death eight months after the symptom onset.
View Article and Find Full Text PDFUndifferentiated embryonal sarcoma of the liver masquerading as a cystadenoma in a young adult: a case report.
J Med Case Rep
November 2024
Department of Radiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, China.
Article Synopsis
- Undifferentiated embryonal sarcoma of the liver is a rare cancer mostly affecting children, and is even less common in adults; proper imaging is crucial to avoid misdiagnosing it with more common liver masses.
- A 37-year-old Chinese woman presented with abdominal pain and underwent multiple imaging tests revealing a cystic-solid liver nodule, initially thought to be benign.
- The definitive indication of malignancy came from a PET-CT scan, which showed abnormal F-fluorodeoxyglucose uptake, prompting the correct diagnosis of undifferentiated embryonal sarcoma of the liver.
The NIPBL-gene mutation of a Cornelia de Lange Syndrome patient causes deficits in the hepatocyte differentiation of induced Pluripotent Stem Cells via altered chromatin-accessibility.
Cell Mol Life Sci
October 2024
Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.
The Cornelia de Lange syndrome (CdLS) is a rare genetic disease, which is characterized by a cohesinopathy. Mutations of the NIPBL gene are observed in 65% of CdLS patients. A novel iPSC (induced Pluripotent Stem Cell) line was reprogrammed from the leukocytes of a CdLS patient carrying a missense mutation of the NIPBL gene.
View Article and Find Full Text PDFPrimary hepatic undifferentiated pleomorphic sarcoma in a young patient.
J Gastrointest Surg
October 2024
Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address:
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