Observations of the subsurface geology of the Moon help advance our understanding of lunar origin and evolution. Radar sounding from the Kaguya spacecraft has revealed subsurface layers at an apparent depth of several hundred meters in nearside maria. Comparison with the surface geology in the Serenitatis basin implies that the prominent echoes are probably from buried regolith layers accumulated during the depositional hiatus of mare basalts. The stratification indicates a tectonic quiescence between 3.55 and 2.84 billion years ago; mare ridges were formed subsequently. The basalts that accumulated during this quiet period have a total thickness of only a few hundred meters. These observations suggest that mascon loading did not produce the tectonics in Serenitatis after 3.55 billion years ago. Global cooling probably dominated the tectonics after 2.84 billion years ago.
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http://dx.doi.org/10.1126/science.1165988 | DOI Listing |
Mol Biol Evol
January 2025
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is an ancient protein critical for CO2-fixation and global biogeochemistry. Form-I RuBisCO complexes uniquely harbor small subunits that form a hexadecameric complex together with their large subunits. The small subunit protein is thought to have significantly contributed to RuBisCO's response to the atmospheric rise of O2 ∼2.
View Article and Find Full Text PDFVaccines (Basel)
November 2024
Bill & Melinda Gates Foundation, Seattle, WA 98109, USA.
Although wild poliovirus type 2 has been eradicated, the prolonged transmission of the live- attenuated virus contained in the type-2 oral polio vaccine (OPV2) in under-immunized populations has led to the emergence of circulating vaccine-derived poliovirus type 2 (cVDPV2). The novel OPV2 (nOPV2) was designed to be more genetically stable and reduce the chance of cVDPV2 emergence while retaining comparable immunogenicity to the Sabin monovalent OPV2 (mOPV2). This study aimed to estimate the relative reduction in the emergence risk due to the use of nOPV2 instead of mOPV2.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Molecular Pathobiology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA.
The notochord is an axial structure required for the development of all chordate embryos, from sea squirts to humans. Over the course of more than half a billion years of chordate evolution, in addition to its structural function, the notochord has acquired increasingly relevant patterning roles for its surrounding tissues. This process has involved the co-option of signaling pathways and the acquisition of novel molecular mechanisms responsible for the precise timing and modalities of their deployment.
View Article and Find Full Text PDFLife (Basel)
November 2024
Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Background: Ageing is a significant risk factor for carotid atherosclerosis, affecting over a billion people worldwide. Carotid intima-media thickness (cIMT) is a surrogate marker for cardiovascular disease (CVD) risk, with age- and sex-related differences in levels and progression. The onset of clinical manifestations of CVD in women is delayed by about 10 years compared to men.
View Article and Find Full Text PDFBiomedicines
December 2024
Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan 33302, Taiwan.
Enteric virus infection is a major public health issue worldwide. Enteric viruses have become epidemic infectious diseases in several countries. Enteric viruses primarily infect the gastrointestinal tract and complete their life cycle in intestinal epithelial cells.
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