AI Article Synopsis
- The study aimed to investigate how Concanavalin A (Con A) affects bone formation during the early and late stages of osteogenesis when demineralized murine incisors are implanted in similar mice.
- Injecting Con A during the early preosteogenic stage increased the bone yield from the implants, but this effect was not seen when Con A was administered after osteogenesis had already started.
- The findings imply that Con A helps attract early bone-forming cells (osteoprogenitor cells) but does not activate more developed cells like chondroblasts and osteoblasts.
Article Abstract
The aim of this study was to examine the effects of Concanavalin A (Con A) administration on the early (preosteogenic) and late stages of osteogenesis induced by implantation of demineralized murine incisors into syngeneic mice. Local administration of Con A resulted in an increased yield of demineralized incisor-induced bone when injected during the preosteogenic stage of induction. This effect was not observed when Con A was injected after heterotopic osteogenesis had been established. This suggests that Con A recruits osteoprogenitor cells, but does not stimulate differentiated chondroblasts and osteoblasts.
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| http://dx.doi.org/10.1080/03008200802690661 | DOI Listing |
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