Starting with a hit from vHTS attained by a docking procedure of virtual compounds into ATP pockets of different kinases applying the 4SCan technology, variations of the adenine mimic resulted in the identification of promising scaffolds, giving rise to in vitro IC(50) values in the nanomolar range on different kinases down to 63nM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2009.01.054 | DOI Listing |
Publication Analysis
Top Keywords
n-substituted 2'-aminoarylbenzothiazoles
4
2'-aminoarylbenzothiazoles kinase
4
kinase inhibitors
4
inhibitors hit
4
hit identification
4
identification scaffold
4
scaffold hopping
4
hopping starting
4
starting hit
4
hit vhts
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!