An efficient and mild method to couple aryl bromides and activated non-allylic alcohols in a Heck reaction with tandem isomerization to selectively afford high yields of 1,5-diarylalkan-1-ones has been developed. Mechanistic insight was gained through NMR studies of products derived from deuterium-labeled intermediates.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/ol900036y | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!