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Characterization of Chitinase 3-like protein 1 spatiotemporal distribution in human post-traumatic brain contusions and other neuropathological scenarios.
J Neuropathol Exp Neurol
January 2025
Neurotraumatology and Subarachnoid Hemorrhage Research Unit, Area 8: Neurosciences and Mental Health, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Chitinase 3-like protein 1 (CHI3L1) is emerging as a promising biomarker for assessing intracranial lesion burden and predicting prognosis in traumatic brain injury (TBI) patients. Following experimental TBI, Chi3l1 transcripts were detected in reactive astrocytes located within the pericontusional cortex. However, the cellular sources of CHI3L1 in response to hemorrhagic contusions in human brain remain unidentified.
View Article and Find Full Text PDFA new selective mediastinal lymph node dissection for clinical peripheral stage IA invasive non-small-cell lung cancer: a propensity-score matching study.
J Thorac Dis
December 2024
The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Background: The optimal extent of lymph node resection for early-stage non-small cell lung cancer (NSCLC) remains a topic of debate in the medical community. We aimed to assess the surgical and prognostic outcomes based on the extent of mediastinal lymph node dissection (MLND) for resectable clinical stage IA NSCLC.
Methods: From 2016 to 2018, 1,166 patients with clinical stage IA NSCLC who underwent lobectomy or segmentectomy with complete mediastinal lymph node dissection (C-MLND) or selective mediastinal lymph node dissection (S-MLND) at five hospitals were enrolled.
[Clinicopathological features and prognosis of rectal neuroendocrine tumor with grade 2].
Zhonghua Zhong Liu Za Zhi
January 2025
Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China.
To explore the clinicopathological features of rectal neuroendocrine tumor (R-NET) G2, identify prognostic factors, and summarize treatment experience. The clinical data of patients diagnosed with R-NET G2 by pathological diagnosis admitted to Cancer Hospital of the Chinese Academy of Medical Sciences from January 2003 to September 2023 were retrospectively analyzed. The Fisher's exact test and Kaplan-Meier curves were performed to analyze the association between pathological features and prognosis.
View Article and Find Full Text PDFJoint replacement for rheumatoid arthritis: When, why, and how! Insights from an orthopedic surgeon.
Best Pract Res Clin Rheumatol
January 2025
Department of Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, 100044, China. Electronic address:
The past several decades have seen significant advancements in joint replacement surgery for rheumatoid arthritis (RA). Joint replacement procedures have become vital options for patients with severe joint damage and functional impairment. There has been an increased emphasis on personalized surgical strategies that tailor joint replacement decisions based on a patient's unique clinical characteristics and the extent of joint damage.
View Article and Find Full Text PDFImpact of the COVID-19 pandemic on the experiences of underrepresented-in-medicine women applicants to surgical residency.
Am J Surg
January 2025
Association of Women Surgeons, Chicago, IL, USA.
Background: The COVID-19 pandemic brought additional challenges to the 2020-2021 application cycle. The objective of this study was to explore how such challenges altered the perceptions/motivations/concerns of applicants to surgical fields, particularly those self-identifying as women underrepresented-in-medicine (UiM).
Methods: An anonymous mixed-methods survey was electronically distributed to all medical student members of the Association of Women Surgeons between 10/1/2020-12/31/2020.
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