The chiral separation of (+/-)-catechin was investigated by capillary electrophoresis using characterized succinyl-beta-cyclodextrins (Suc-beta-CDs) with one to three degree of substitution values. The effects of nature and concentration of Suc-beta-CDs and running buffer pH on the migration time and resolution of (+/-)-catechin are discussed. All three kinds of Suc-beta-CDs show a clear baseline separation of (+/-)-catechin in capillary electrophoresis. Mono-Suc-beta-CD effectively separated (+/-)-catechin, and additional substituted CDs (di- and tri-Suc-beta-CD) were capable of chiral separation at a broad pH range. The optimum running conditions were found to be 100 mM borate buffer (pH 9.8) containing 5 mM mono-Suc-beta-CD with no methanol organic modifier.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chir.20696 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preparation of a 1,1'-Binaphthyl-based Chiral Polyimine Macrocycle Bonded Chiral Stationary Phase by Thiol-ene Click Reaction and Its Enantioseparation Performance in High-Performance Liquid Chromatography.
J Sep Sci
December 2024
College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China.
Chiral macrocycles have emerged as attractive media for chromatographic enantioseparation due to their excellent host-guest recognition properties. In this study, a new chiral stationary phase (CSP) based on 1,1'-binaphthyl chiral polyimine macrocycle (CPM) was reported. The CPM was synthesized by one-step aldehyde-amine condensation of (S)-2,2'-dihydroxy-[1,1'-binaphthalene]-3,3'-dicarboxaldehyde with 1,2-phenylenediamine and bonded on thiolated silica via the thiol-ene click reaction to afford the CSP.
View Article and Find Full Text PDFNMR-based structure elucidation and chiral separation of N-cyclohexylmethylone, a novel designer drug.
Forensic Sci Int
December 2024
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstraße 1, Graz A-8010, Austria. Electronic address:
Synthetic cathinones belong to one of the biggest and most popular classes of New Psychoactive Substances. Each year, new derivatives appear on the drug market, traded under various labels like "bath salts" or "legal highs". In recent years, the emergence of new cathinone derivatives, containing a cyclohexyl residue, has been observed.
View Article and Find Full Text PDFIn this Letter, we have proposed an all-optical scheme for chiral particle separation with a microcylinder-pair system (MCPS) with a micrometer scale channel, applicable in microfluidic environments. By illuminating the MCPS with two counter-incident plane waves of orthogonal polarization, the electromagnetic chirality gradient can be generated. The MCPS can also enhance chirality-dependent lateral optical forces of the coupled fields so that the setup can shift trapping equilibrium positions for opposite-handedness nanoparticles and make the sideways motion observable.
View Article and Find Full Text PDFConstruction of Chirality-Sorting Optical Force Pairs.
Phys Rev Lett
December 2024
Optics Research Group, Delft University of Technology, Department of Imaging Physics, Lorentzweg 1, 2628CJ Delft, The Netherlands.
Chiral objects are abundant in nature, and although the enantiomers have almost identical physical properties apart from their handedness, they can exhibit significantly different chemical properties and biological functions. This underscores the importance of sorting chiral substances. In this Letter, we demonstrate that chirality-sorting optical force pairs can be inversely generated in a tightly focused Gaussian beam by tailoring the input polarization state.
View Article and Find Full Text PDFRenal Clearable Chiral Manganese Oxide Supraparticles for In Vivo Detection of Metalloproteinase-9 in Early Cancer Diagnosis.
Adv Mater
December 2024
State Key Laboratory of Food Science and Technology, International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
In this study, polypeptide TGGGPLGVARGKGGC-induced chiral manganese dioxide supraparticles (MnO SPs) are prepared for sensitive quantification of matrix metalloproteinase-9 (MMP-9) in vitro and in vivo. The results show that L-type manganese dioxide supraparticles (L-MnO SPs) exhibited twice the affinity for the cancer cell membrane receptor CD47 (cluster of differentiation, integrin-associated protein) than D-type manganese dioxide supraparticles (D-MnO SPs) to accumulate at the tumor site after surface modification of the internalizing arginine-glycine-aspartic acid (iRGD) ligand, specifically reacting with the MMP-9, disassembling into ultrasmall nanoparticles (NPs), and efficiently underwent renal clearance. Furthermore, L-MnO facilitates the quantification of MMP-9 in mouse tumor xenografts, as demonstrated by circular dichroism (CD) and magnetic resonance imaging (MRI) within 2 h.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!