Photothrombosis of the vessels in the prefrontal areas of the rat cortex 20 days before learning leads to development of ischemic infarction in the exposed area with profound deficits in acquisition of the Morris water maze task: length of path and time of search of hidden-platform in water maze increased vs false-operated rats. It suggests prefrontal cortex involvement in spatial navigation.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Background: Diabetes is known to cause cognitive impairments and synaptic dysfunction. This study investigates the effects of (EO), (CT), Vitamin C, and metformin on cognitive function and synaptic density (SYN) in diabetic rats. This work aims to evaluate the impact of various treatments on spatial learning, memory, and SYN in a diabetic rat model.
View Article and Find Full Text PDFEffects of a Serotonin Receptor Peptide on Behavioral Pattern Separation in Sham- vs. Mild Traumatic Brain Injured Rats.
Endocrinol Diabetes Metab J
June 2024
Medical & Research Services, Veterans Affairs New Jersey Healthcare System, East Orange, New Jersey, USA.
Aims: Behavioral pattern separation is a hippocampal-dependent component of episodic memory and a sensitive marker of early cognitive decline. Here we tested whether mild traumatic injury causes loss of pattern separation in the rat and for its prevention by a novel neuroprotective peptide fragment of the human serotonin 2A receptor (SN..
View Article and Find Full Text PDFIntroduction: CLN8-Batten disease is a rare neurodegenerative disorder characterized phenotypically by progressive deterioration of motor and cognitive abilities, visual symptoms, epileptic seizures, and premature death. Mutations in CLN8 result in characteristic Batten disease symptoms and brain-wide pathology including accumulation of lysosomal storage material, gliosis, and neurodegeneration. Recent investigations of other subtypes of Batten disease (CLN1, CLN3, CLN6) have emphasized the influence of biological sex on disease and treatment outcomes; however, little is known about sex differences in the CLN8 subtype.
View Article and Find Full Text PDF1-Methylxanthine enhances memory and neurotransmitter levels.
PLoS One
January 2025
Radiant Research Services Pvt. Ltd., Bangalore, India.
1-Methylxanthine (1-MX) is the major metabolite of caffeine and paraxanthine and might contribute to their activity. 1-MX is an adenosine receptor antagonist and increases the release and survivability of neurotransmitters; however, no study has addressed the potential physiological effects of 1-MX ingestion. The aim of this study was to compare the effect of 1-MX on memory and related biomarkers in rats compared to control.
View Article and Find Full Text PDFComparison of two independent populations of compositional data with positive correlations among components using a nested dirichlet distribution.
Psychol Methods
January 2025
Department of Statistics and Data Science, Southern Methodist University.
Compositional data are multivariate data made up of components that sum to a fixed value. Often the data are presented as proportions of a whole, where the value of each component is constrained to be between 0 and 1 and the sum of the components is 1. There are many applications in psychology and other disciplines that yield compositional data sets including Morris water maze experiments, psychological well-being scores, analysis of daily physical activity times, and components of household expenditures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!