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Immune-Complex Mediated Mesangial Proliferative Glomerulonephritis with Full-House Pattern Observed During Treatment of Immune Thrombocytopenic Purpura.
Clin Med Insights Case Rep
December 2024
Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Japan.
This study reports a rare case of immune-complex mediated mesangial proliferative glomerulonephritis (ICGN) with a full-house pattern in a 56-year-old Japanese man, observed during the treatment of immune thrombocytopenic purpura (ITP). Because of persistent complement deficiency and worsening of kidney function, he was treated with prednisolone, and his urinary findings improved markedly. However, as the complement titers were still low, mycophenolate mofetil was also prescribed, which normalized complement levels.
View Article and Find Full Text PDFPharmacokinetics/pharmacodynamics of glucocorticoids: modeling the glucocorticoid receptor dynamics and dose/response of commonly prescribed glucocorticoids.
ADMET DMPK
October 2024
Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Background And Purpose: The main features of the dynamics of the glucocorticoid receptor (GR) have been known for 50 years: 1) in the absence of glucocorticoid (G), the receptor is localized entirely in the cytoplasm; 2) upon G binding, GR is converted into a tightly bound G form and is rapidly imported into the nucleus where it can bind DNA and modulate transcription; 3) nuclear export of GR is very slow; and 4) the nuclear form of GR can recycle through an unbound form, back to the bound transcription modulating form without leaving the nucleus.
Experimental Approach: A kinetic model that captures these features is presented, a set of model parameters for dexamethasone is derived, and the clinical implication for the commonly used glucocorticoids is discussed.
Key Results: At the high concentrations normally used to describe G pharmacodynamics, the model reduces to the standard Michaelis-Menten equation with a that is a function of 4 model parameters.
A Case of Infective Endocarditis Following Bone Marrow Transplantation for Myelodysplastic Syndrome.
Cureus
November 2024
Cardiovascular Surgery, Sapporo Medical University, Sapporo, JPN.
A 63-year-old man was diagnosed with myelodysplastic syndrome (MDS) at the age of 62 by the hematology department. The patient underwent four cycles of azacitidine (AZA) therapy, followed by successful bone marrow transplantation (BMT). Subsequently, he was hospitalized twice for graft-versus-host disease (GVHD).
View Article and Find Full Text PDFEpidemiology and treatment of Adamantiades-Behçet's disease in Germany: A healthcare claims database study.
J Eur Acad Dermatol Venereol
December 2024
WIG2 GmbH Scientific Institute for Health Economics and Health System Research, Leipzig, Germany.
Background: Adamantiades-Behçet's disease (ABD) is a rare, chronic, relapsing, multisystem vasculitis, with a reported prevalence of 0.9 out of 100,000 population in Germany in 2012. However, more recent epidemiological data are lacking.
View Article and Find Full Text PDFNeonatal Hyperbilirubinemia: A Case of Complex Management Involving ABO Incompatibility, Sepsis, and Suspected G6PD Deficiency treated with Methyl Prednisolone.
Niger Med J
November 2024
Department of Paediatrics, Abubakar Tafawa Balewa University Teaching Hospital, Bauchi, Nigeria.
Article Synopsis
- * A case study involved a 22-hour-old neonate with severe hyperbilirubinemia due to ABO incompatibility, where traditional treatments were ineffective, leading to the off-label use of low-dose intravenous methylprednisolone, which improved the condition rapidly.
- * Managing severe NNJ poses challenges, especially in resource-limited settings, highlighting the need for further research on immunomodulatory treatments like methylprednisolone to assess their safety and effectiveness.
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