AI Article Synopsis
- The study compared anxiety levels and treatment outcomes between women taking fluoxetine and a placebo during four stressful IVF stages.
- Anxiety increased for both groups during the IVF process, with significant changes noted in STAI scores.
- The research concluded that fluoxetine may not effectively reduce anxiety in IVF patients without impacting treatment outcomes, suggesting further investigation into other SSRIs or higher doses.
Article Abstract
Objective: To compare anxiety levels experienced during 4 stressful periods of in vitro fertilization (IVF) and treatment outcomes between women taking fluoxetine and a placebo.
Methods: A prospective, randomized, double-blind, placebo-controlled trial of patients allocated to receive either fluoxetine (FLX) or folic acid (FA). Anxiety state was assessed at the beginning of ovarian stimulation (OS), ovum pick-up, embryo transfer, and on the day of the pregnancy test (DPT) using the State-Trait Anxiety Inventory (STAI).
Results: Baseline STAI-S and STAI-T were normal. From OS to DPT, STAI-S increased from 42.8+/-10.6 to 44+/-9.0 in the FLX group and from 40.9+/-8.1 to 45.3+/-8.3 in the FA group (P=0.03 and P=0.001, respectively). IVF outcome was not affected by the treatment in the two groups.
Conclusions: Caution is needed in prescribing fluoxetine to alleviate anxiety in patients undergoing IVF. Studies are needed to determine whether other selective serotonin reuptake inhibitors or higher fluoxetine doses can relieve emotional distress without affecting IVF outcome.
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| http://dx.doi.org/10.1016/j.ijgo.2008.12.013 | DOI Listing |
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