Objective: To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.
Methods: Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.
Results: Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.
Conclusion: The SRY gene is key in sex determination and development, yet there might be other important genes involved.
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| http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2009.01.022 | DOI Listing |
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