AI Article Synopsis
- Caboxamycin is a newly identified antibiotic from a marine strain of Streptomyces sp. NTK 937, found in deep-sea sediment of the Canary Basin.
- Its structure was confirmed using techniques such as mass spectrometry, NMR, and X-ray analysis.
- The antibiotic demonstrated effectiveness against Gram-positive bacteria, certain human tumor cell lines, and the enzyme phosphodiesterase.
Article Abstract
Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.
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| http://dx.doi.org/10.1038/ja.2008.24 | DOI Listing |
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