AI Article Synopsis
- A 66-year-old man with asbestosis was diagnosed with a primary localized malignant biphasic mesothelioma of the liver, identified as a 4 cm nodule in the right lobe during a CT scan.
- Histopathological analysis revealed diverse tumor patterns, including papillary epithelioid, microcystic, and sarcomatoid components, with specific immunoreactivity to mesothelial markers and absence of adenocarcinoma markers.
- This case is noteworthy as it's the first documented instance of biphasic mesothelioma in the liver, contrasting with previous reports which only identified epithelioid types.
Article Abstract
We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653355 | PMC |
| http://dx.doi.org/10.3748/wjg.15.615 | DOI Listing |
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